The San Francisco 49ers play 17 regular-season games in 2026 — 9 at home and 8 on the road, with their bye in Week 8. They open against the Rams on Thursday, September 10.
They have 5 primetime games: Week 1 against the Rams (TNF), Week 6 against the Commanders (MNF), Week 11 against the Vikings (SNF), Week 15 at the Chargers (TNF) and Week 17 against the Eagles (SNF).
Through Week 5 the San Francisco 49ers are 5-0 — 3-0 at home and 2-0 on the road.
The Statz season simulation projects 13 wins (a 11–15 win range) and a 97.5% chance of making the playoffs.
| Week | Date | Opponent | Result or kickoff |
|---|---|---|---|
| Week 1 | THU 9/10 | at Los Angeles Rams | W 27–7 |
| Week 2 | SUN 9/20 | vs Miami Dolphins | W 35–13 |
| Week 3 | SUN 9/27 | vs Arizona Cardinals | W 36–30 |
| Week 4 | SUN 10/4 | vs Denver Broncos | W 24–14 |
| Week 5 | SUN 10/11 | at Seattle Seahawks | W 32–29 |
| Week 6 | MON 10/19 | vs Washington Commanders | 8:15 PM ET |
| Week 7 | SUN 10/25 | at Atlanta Falcons | 1:00 PM ET |
| Week 8 | Bye week | ||
| Week 9 | SUN 11/8 | vs Las Vegas Raiders | 4:05 PM ET |
| Week 10 | SUN 11/15 | at Dallas Cowboys | 4:25 PM ET |
| Week 11 | SUN 11/22 | vs Minnesota Vikings | 8:20 PM ET |
| Week 12 | SUN 11/29 | vs Seattle Seahawks | 4:25 PM ET |
| Week 13 | SUN 12/6 | at New York Giants | 1:00 PM ET |
| Week 14 | SUN 12/13 | vs Los Angeles Rams | 4:25 PM ET |
| Week 15 | THU 12/17 | at Los Angeles Chargers | 8:15 PM ET |
| Week 16 | SUN 12/27 | at Kansas City Chiefs | 4:25 PM ET |
| Week 17 | SUN 1/3 | vs Philadelphia Eagles | 8:20 PM ET |
| Week 18 | SUN 1/10 | at Arizona Cardinals | Time TBD |