Philadelphia Eagles vs San Francisco 49ers Prediction, Odds & Props — Week 17

The Philadelphia Eagles visit the San Francisco 49ers in Week 17 of the 2026 NFL season, on Sunday, January 3 at 8:20 PM ET at Levi's Stadium. Open air · Grass. The Eagles are 2-7 (4th in the NFC East), the 49ers 7-1 (1st in the NFC West). The Eagles went 0-6 down the stretch, the 49ers 5-1.

In 2026 the Eagles scored 16.4 points per game (30th in the NFL) and allowed 24.6 (19th in the NFL); the 49ers scored 29.4 (3rd in the NFL) and allowed 19.5 (6th in the NFL).

Head-to-head, the recent series reads SF 3–2 over the last 5 meetings, at an average total of 42.8; against the spread it is SF 3–2, and the total has gone UNDER 4–1. SF have taken 3 of the last 5 — 3 of the 5 landed inside a score.

Injury report: 25 players out and 26 questionable across the two teams — Gracen Halton (SF DT, Injured reserve), C.J. West (SF DT, Injured reserve), Brandon Aiyuk (SF WR, Out) and DeVonta Smith (PHI WR, Out).

All Eagles v 49ers games

Philadelphia Eagles vs San Francisco 49ers: team comparison (2026 season, NFL rank in brackets)
Philadelphia EaglesSan Francisco 49ers
Record2-77-1
Division4th NFC E1st NFC W
Last six resultsL L L L L LW W W W L W
Points / G16.4 (30th)29.4 (3rd)
Total Yds / G281.9 (32nd)382.8 (7th)
Yards / Play4.6 (32nd)6.4 (1st)
Pass Yds / G193.3 (26th)247.5 (14th)
Rush Yds / G88.6 (28th)135.3 (7th)
3rd Down %35.9% (25th)51.7% (2nd)
1st Downs / G15.8 (31st)22.0 (6th)
Turnover Diff-4 (27th)+1 (13th)
Pts Allowed / G24.6 (19th)19.5 (6th)
Yds Allowed / G365 (24th)303.8 (2nd)
Pass Yds Allowed238.9 (19th)222.9 (9th)
Rush Yds Allowed126.1 (24th)80.9 (2nd)
Sacks16 (26th)15 (28th)
  • Philadelphia Eagles stats, schedule and roster
  • San Francisco 49ers stats, schedule and roster
Philadelphia Eagles vs San Francisco 49ers injury report
PlayerTeamPositionStatusInjury
Gracen HaltonSFDTInjured reserveQuadricep
Mike EvansSFWRQuestionableRibs
Deebo Samuel Sr.SFWRQuestionableHamstring
C.J. WestSFDTInjured reserveUndisclosed
Deommodore LenoirSFCBQuestionableFoot
Renardo GreenSFCBQuestionableHamstring
Brandon AiyukSFWROutPersonal
DeVonta SmithPHIWROutHamstring
Dontayvion WicksPHIWROutAnkle
Britain CoveyPHIWROutKnee
Jihaad CampbellPHILBOutHamstring
Jonathan JonesPHICBOutHamstring
Michael Carter IIPHICBOutAbdomen
Zack BaunPHILBQuestionableShoulder
Nate HobbsSFCBIR, designated to returnGroin
Christian KirkSFWRInjured reserveKnee
Dameon PiercePHIRBQuestionableUndisclosed
De'Zhaun StriblingSFWRInjured reserveAnkle
Lane JohnsonPHIOTOut
Brett TothSFCQuestionableConcussion
Jalen HurtsPHIQBInjured reserveCalf
Will ShipleyPHIRBInjured reserveFoot
Nick MartinSFLBInjured reserveHamstring
Chance CampbellPHILBQuestionable
Uar BernardPHIDTOutUndisclosed
Tank BigsbyPHIRBInjured reserveAbdomen
Jake TongesSFTEInjured reserveKnee
Alfred CollinsSFDTInjured reserveKnee
Sam OkuayinonuSFDTInjured reserve
Andre' SamPHISInjured reserveFoot
Nick ZakeljSFOTInjured reserveUndisclosed
Austen PleasantsSFOTIR, designated to returnKnee
Isaac GuerendoSFRBReserve/PUPPectoral
Tariq Castro-FieldsPHICBQuestionableHeel
Johnny WilsonPHIWRInjured reserveKnee
Ricky PearsallSFWRInjured reserve
Mikail KamaraSFDEInjured reserve
Andrew Farmer IISFDEInjured reserveBack
Darrick ForrestSFSInjured reserveUndisclosed
Tucker LargePHISOut
Cam JurgensPHICQuestionable
Carson SteelePHIRBInjured Reserve
Danny GrayPHIWRQuestionable
Jakorian BennettPHICBInjured Reserve
Ben VanSumerenPHIFBInjured Reserve
Hollywood BrownPHIWRQuestionable
Ja'Quinden JacksonPHIRBInjured Reserve
Micah MorrisPHIGQuestionable
John OjukwuPHIOTQuestionable
Makai LemonPHIWRQuestionable
Shaun WadePHICBQuestionable
Cooper DeJeanPHICBQuestionable
Robert JonesSFGQuestionable
Patrick Taylor Jr.SFRBInjured Reserve
Trent TaylorSFWRInjured Reserve
Tre TomlinsonSFCBQuestionable
William Bradley-KingSFDEInjured Reserve
Tarron JacksonSFDEInjured Reserve
Tanner McLachlanSFTEInjured Reserve
Titus LeoSFDEInjured Reserve
Xavier ThomasSFLBInjured Reserve
Naquan JonesSFDTOut
Malik MustaphaSFSQuestionable
Dre GreenlawSFLBQuestionable
Luke GiffordSFLBQuestionable
Mykel WilliamsSFDEOut
Nick BosaSFDEQuestionable
Siran NealSFSQuestionable
Demarcus RobinsonSFWRInjured Reserve
Romello HeightSFDEQuestionable
KhaDarel HodgeSFWRQuestionable
Victor DimukejeSFDEInjured Reserve

SF have taken 3 of the last 5 — 3 of the 5 landed inside a score.

Recent meetings
GameWinnerScoreVenue
2025 WCSF23–19Lincoln Financial Field
2023 Week 13SF42–19Lincoln Financial Field
2022 CONFPHI31–7Lincoln Financial Field
2021 Week 2SF17–11Lincoln Financial Field
2020 Week 4PHI25–20Levi's Stadium

Frequently asked questions

When do the Eagles play the 49ers?

Philadelphia Eagles at San Francisco 49ers is Week 17 of the 2026 NFL season, kicking off on Sunday, January 3 at 8:20 PM ET at Levi's Stadium.

What is the head-to-head record between the Eagles and the 49ers?

The recent series is SF 3–2 over the last 5 meetings — the last one finished SF 23–19 in 2025 (WC), and against the spread the series is SF 3–2.

Who is injured for Eagles vs 49ers?

72 players carry a designation: 25 out and 26 questionable, including Gracen Halton (SF DT, Injured reserve), C.J. West (SF DT, Injured reserve), Brandon Aiyuk (SF WR, Out) and DeVonta Smith (PHI WR, Out).

Eagles v 49ers: teams and standings

  • Philadelphia Eagles
  • Philadelphia Eagles Stats
  • San Francisco 49ers
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  • NFL Power Rankings this week

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