Isaac Guerendo Stats, Game Log & Props — 49ers RB

Isaac Guerendo is a running back for the San Francisco 49ers, who took him 129th overall in the 2024 NFL Draft out of Louisville. In 2024 he posted 420 rushing yards — 44th among RBs — with 4 touchdowns over 16 games. Born June 28, 2000, he is in his 3rd season in the league.

Isaac Guerendo 2025 rushing stats (14 games)
Stat	Total	Rank
Carries	—
Yards	—
Touchdowns	—
Yards per attempt	—
Yards per game	—
First downs	—
Fumbles	—

Isaac Guerendo last 10 games
Game	Opponent	Result	Carries	Rushing yards	Longest rush
2025 Week 13	at Cleveland Browns	W 26–8	0	0	0
2025 Week 9	at New York Giants	W 34–24	0	0	0
2025 Week 7	vs Atlanta Falcons	W 20–10	0	0	0
2025 Week 5	at Los Angeles Rams	W 26–23	0	0	0
2025 Week 3	vs Arizona Cardinals	W 16–15	0	0	0
2025 Week 2	at New Orleans Saints	W 26–21	0	0	0
2025 Week 1	at Seattle Seahawks	W 17–13	0	0	0
2024 Week 18	at Arizona Cardinals	L 24–47	2	5	3
2024 Week 17	vs Detroit Lions	L 34–40	9	34	11
2024 Week 15	vs Los Angeles Rams	L 6–12	16	57	16

Frequently asked questions

How did Isaac Guerendo perform in Week 13 of 2025?

Guerendo ran 0 times for 0 yards in San Francisco's 26–8 win over Cleveland.

Is Isaac Guerendo injured?

Isaac Guerendo is listed as Reserve/PUP (pectoral) on the latest injury report — on the reserve/PUP list — must miss at least the first four games of the season, then becomes eligible to return.

How old is Isaac Guerendo?

Isaac Guerendo is 26 years old — he was born on June 28, 2000.

How tall is Isaac Guerendo?

Isaac Guerendo is 6' 0" tall and weighs 221 lbs.

What position does Isaac Guerendo play?

Isaac Guerendo is a running back for the San Francisco 49ers and wears No. 31.

Where did Isaac Guerendo go to college?

Isaac Guerendo played college football at Louisville.

When was Isaac Guerendo drafted?

The San Francisco 49ers drafted Isaac Guerendo 129th overall in the 2024 NFL Draft.