San Francisco 49ers vs Kansas City Chiefs Prediction, Odds & Props — Week 16

The San Francisco 49ers visit the Kansas City Chiefs in Week 16 of the 2026 NFL season, on Sunday, December 27 at 4:25 PM ET at Arrowhead Stadium. Open air · Grass. The 49ers are 7-1 (1st in the NFC West), the Chiefs 6-2 (2nd in the AFC West). The 49ers went 5-1 down the stretch, the Chiefs 4-2.

In 2026 the 49ers scored 29.4 points per game (3rd in the NFL) and allowed 19.5 (6th in the NFL); the Chiefs scored 25.3 (10th in the NFL) and allowed 17.9 (3rd in the NFL).

Head-to-head, the recent series reads KC 5–0 over the last 5 meetings, at an average total of 55.2; against the spread it is KC 5–0, and the total has gone OVER 2–2. KC have won all 5 recent meetings and are unbeaten at home in the series — 1 of the 5 landed inside a score.

Injury report: 23 players out and 23 questionable across the two teams — C.J. West (SF DT, IR, designated to return), Mansoor Delane (KC CB, Out), Gracen Halton (SF DT, Injured reserve) and Brandon Aiyuk (SF WR, Out).

All 49ers v Chiefs games

• San Francisco 49ers stats, schedule and roster
• Kansas City Chiefs stats, schedule and roster

KC have won all 5 recent meetings and are unbeaten at home in the series — 1 of the 5 landed inside a score.