The San Francisco 49ers visit the Kansas City Chiefs in Week 16 of the 2026 NFL season, on Sunday, December 27 at 4:25 PM ET at Arrowhead Stadium. Open air · Grass. The 49ers are 3-0 (1st in the NFC West), the Chiefs 3-0 (2nd in the AFC West). The 49ers went 4-2 down the stretch, the Chiefs 3-3.
In 2026 the 49ers scored 31 points per game (4th in the NFL) and allowed 10 (3rd in the NFL); the Chiefs scored 32 (3rd in the NFL) and allowed 20 (11th in the NFL).
Head-to-head, the recent series reads KC 5–0 over the last 5 meetings, at an average total of 55.2; against the spread it is KC 5–0, and the total has gone OVER 2–2. KC have won all 5 recent meetings and are unbeaten at home in the series — 1 of the 5 landed inside a score.
Injury report: 19 players out and 26 questionable across the two teams — Demarcus Robinson (SF WR, Injured reserve), James Thompson Jr. (SF DT, Out), Romello Height (SF DE, Out) and Nick Bosa (SF DE, Out).
Frequently asked questions
When do the 49ers play the Chiefs?
San Francisco 49ers at Kansas City Chiefs is Week 16 of the 2026 NFL season, kicking off on Sunday, December 27 at 4:25 PM ET at Arrowhead Stadium.
What is the head-to-head record between the 49ers and the Chiefs?
The recent series is KC 5–0 over the last 5 meetings — the last one finished KC 28–18 in 2024 (Week 7), and against the spread the series is KC 5–0.
Who is injured for 49ers vs Chiefs?
82 players carry a designation: 19 out and 26 questionable, including Demarcus Robinson (SF WR, Injured reserve), James Thompson Jr. (SF DT, Out), Romello Height (SF DE, Out) and Nick Bosa (SF DE, Out). The report refreshes with the data sync before game days and the model prices designations in automatically.