The San Francisco 49ers visit the Arizona Cardinals in Week 18 of the 2026 NFL season, on Sunday, January 10 at 12:00 AM ET at State Farm Stadium. Grass. The 49ers are 3-0 (1st in the NFC West), the Cardinals 1-2 (4th in the NFC West). The 49ers went 4-2 down the stretch, the Cardinals 1-5.
In 2026 the 49ers scored 31 points per game (4th in the NFL) and allowed 10 (3rd in the NFL); the Cardinals scored 16.5 (25th in the NFL) and allowed 22.5 (14th in the NFL).
Head-to-head, the recent series reads SF 4–2 over the last 6 meetings, at an average total of 58.7; against the spread it is ARI 4–2, and the total has gone OVER 4–2. SF have taken 4 of the last 6 — 3 of the 6 landed inside a score.
Injury report: 18 players out and 30 questionable across the two teams — Demarcus Robinson (SF WR, Injured reserve), C.J. West (SF DT, Injured reserve), Will Johnson (ARI CB, Injured reserve) and Brandon Aiyuk (SF WR, Did not report).
Frequently asked questions
When do the 49ers play the Cardinals?
San Francisco 49ers at Arizona Cardinals is Week 18 of the 2026 NFL season, kicking off on Sunday, January 10 at 12:00 AM ET at State Farm Stadium.
What is the head-to-head record between the 49ers and the Cardinals?
The recent series is SF 4–2 over the last 6 meetings — the last one finished SF 36–30 in 2026 (Week 3), and against the spread the series is ARI 4–2.
Who is injured for 49ers vs Cardinals?
91 players carry a designation: 18 out and 30 questionable, including Demarcus Robinson (SF WR, Injured reserve), C.J. West (SF DT, Injured reserve), Will Johnson (ARI CB, Injured reserve) and Brandon Aiyuk (SF WR, Did not report). The report refreshes with the data sync before game days and the model prices designations in automatically.