San Francisco 49ers vs Arizona Cardinals Prediction, Odds & Props — Week 18

The San Francisco 49ers visit the Arizona Cardinals in Week 18 of the 2026 NFL season, on Sunday, January 10 at 12:00 AM ET at State Farm Stadium. Grass. The 49ers are 7-1 (1st in the NFC West), the Cardinals 3-6 (4th in the NFC West). The 49ers went 5-1 down the stretch, the Cardinals 2-4.

In 2026 the 49ers scored 29.4 points per game (3rd in the NFL) and allowed 19.5 (6th in the NFL); the Cardinals scored 19.8 (26th in the NFL) and allowed 28.3 (31st in the NFL).

Head-to-head, the recent series reads SF 4–2 over the last 6 meetings, at an average total of 58.7; against the spread it is ARI 4–2, and the total has gone OVER 4–2. SF have taken 4 of the last 6 — 3 of the 6 landed inside a score.

Injury report: 24 players out and 32 questionable across the two teams — Zachary Carter (ARI DT, IR, designated to return), C.J. West (SF DT, IR, designated to return), Hunter Long (ARI TE, IR, designated to return) and Gardner Minshew II (ARI QB, Injured reserve).

All 49ers v Cardinals games

• San Francisco 49ers stats, schedule and roster
• Arizona Cardinals stats, schedule and roster

SF have taken 4 of the last 6 — 3 of the 6 landed inside a score.