49ers vs Cardinals: head to head

Frequently asked questions

Who leads the 49ers vs Cardinals series?

The 49ers lead 10-7 over the 17 games since 2018.

When did the 49ers last play the Cardinals?

27 September 2026, in Week 3 of the 2026 season: the 49ers won 36-30 at Levi's Stadium.

What is the average score when the 49ers play the Cardinals?

49.8 points a game: the 49ers average 27.1 and the Cardinals 22.8 in their 17 meetings since 2018.

What is the biggest win in the 49ers vs Cardinals series?

The 49ers won by 28, 38-10, in Week 11 of 2022.

When do the 49ers play the Cardinals next?

Sunday 10 January 2027 (kickoff time to be set), in Week 18: the 49ers at the Cardinals, State Farm Stadium.