The Denver Broncos visit the San Francisco 49ers in Week 4 of the 2026 NFL season, on Sunday, October 4 at 4:25 PM ET at Levi's Stadium. Open air · Grass. The Broncos are 1-1 (3rd in the AFC West), the 49ers 2-0 (1st in the NFC West). The Broncos went 4-2 down the stretch, the 49ers 4-2.
In 2026 the Broncos scored 15 points per game (29th in the NFL) and allowed 22 (13th in the NFL); the 49ers scored 31 (4th in the NFL) and allowed 10 (3rd in the NFL).
Head-to-head, the recent series reads SF 1–1 over the last 2 meetings, at an average total of 27.5; against the spread it is SF 1–1, and the total has gone UNDER 2–0. The last 2 meetings are split 1–1 — 2 of the 2 landed inside a score.
Injury report: 15 players out and 20 questionable across the two teams — Demarcus Robinson (SF WR, Injured reserve), Jonah Coleman (DEN RB, Injured reserve), James Thompson Jr. (SF DT, Out) and Romello Height (SF DE, Out).
Frequently asked questions
When do the Broncos play the 49ers?
Denver Broncos at San Francisco 49ers is Week 4 of the 2026 NFL season, kicking off on Sunday, October 4 at 4:25 PM ET at Levi's Stadium.
What is the head-to-head record between the Broncos and the 49ers?
The recent series is SF 1–1 over the last 2 meetings — the last one finished DEN 11–10 in 2022 (Week 3), and against the spread the series is SF 1–1.
Who is injured for Broncos vs 49ers?
73 players carry a designation: 15 out and 20 questionable, including Demarcus Robinson (SF WR, Injured reserve), Jonah Coleman (DEN RB, Injured reserve), James Thompson Jr. (SF DT, Out) and Romello Height (SF DE, Out). The report refreshes with the data sync before game days and the model prices designations in automatically.