San Francisco 49ers vs Dallas Cowboys Prediction, Odds & Props — Week 10

The San Francisco 49ers visit the Dallas Cowboys in Week 10 of the 2026 NFL season, on Sunday, November 15 at 4:25 PM ET at AT&T Stadium. Matrixturf. The 49ers are 7-1 (1st in the NFC West), the Cowboys 4-5 (2nd in the NFC East). The 49ers went 5-1 down the stretch, the Cowboys 3-3.

The market has SF -4.0 with a total of 55.5.

In 2026 the 49ers scored 29.4 points per game (3rd in the NFL) and allowed 19.5 (6th in the NFL); the Cowboys scored 27.3 (6th in the NFL) and allowed 26.2 (26th in the NFL).

Head-to-head, the recent series reads SF 4–1 over the last 5 meetings, at an average total of 50.2; against the spread it is SF 4–1, and the total has gone OVER 3–2. SF have taken 4 of the last 5 — 4 of the 5 landed inside a score.

Injury report: 25 players out and 23 questionable across the two teams — C.J. West (SF DT, IR, designated to return), Luke Schoonmaker (DAL TE, Out), Devin Moore (DAL CB, IR, designated to return) and Gracen Halton (SF DT, Injured reserve).

Best price across 8 sportsbooks: SF -190 at Polymarket and DAL +199 at Kalshi on the moneyline, the spread DAL +3.5 (+106) and the total 24.5 (over +100). The Props tab prices 48 player props for this game — passing, rushing and receiving yards, receptions and anytime touchdown markets — at Bet365's lines.

All 49ers v Cowboys games

• San Francisco 49ers stats, schedule and roster
• Dallas Cowboys stats, schedule and roster

SF have taken 4 of the last 5 — 4 of the 5 landed inside a score.