Minnesota Vikings vs San Francisco 49ers Prediction, Odds & Props — Week 11

The Minnesota Vikings visit the San Francisco 49ers in Week 11 of the 2026 NFL season, on Sunday, November 22 at 8:20 PM ET at Estadio Banorte. Open air · Grass. The Vikings are 6-2 (3rd in the NFC North), the 49ers 7-1 (1st in the NFC West). The Vikings went 4-2 down the stretch, the 49ers 5-1.

In 2026 the Vikings scored 18.3 points per game (27th in the NFL) and allowed 14.5 (1st in the NFL); the 49ers scored 29.4 (3rd in the NFL) and allowed 19.5 (6th in the NFL).

Head-to-head, the recent series reads MIN 3–2 over the last 5 meetings, at an average total of 43.2; against the spread it is MIN 3–2, and the total has gone UNDER 4–1. MIN have taken 3 of the last 5 and are unbeaten at home in the series — 4 of the 5 landed inside a score.

Injury report: 25 players out and 25 questionable across the two teams — C.J. West (SF DT, IR, designated to return), Kyler Murray (MIN QB, Doubtful), Gracen Halton (SF DT, Injured reserve) and Demond Claiborne (MIN RB, Injured reserve).

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• Minnesota Vikings stats, schedule and roster
• San Francisco 49ers stats, schedule and roster

MIN have taken 3 of the last 5 and are unbeaten at home in the series — 4 of the 5 landed inside a score.