Los Angeles Rams vs San Francisco 49ers Prediction, Odds & Props — Week 14

The Los Angeles Rams visit the San Francisco 49ers in Week 14 of the 2026 NFL season, on Sunday, December 13 at 4:25 PM ET at Levi's Stadium. Open air · Grass. The Rams are 5-4 (2nd in the NFC West), the 49ers 7-1 (1st in the NFC West). The Rams went 4-2 down the stretch, the 49ers 5-1.

In 2026 the Rams scored 23.8 points per game (13th in the NFL) and allowed 20.1 (8th in the NFL); the 49ers scored 29.4 (3rd in the NFL) and allowed 19.5 (6th in the NFL).

Head-to-head, the recent series reads LAR 4–2 over the last 6 meetings, at an average total of 43.5; against the spread it is LAR 4–2, and the total has gone OVER 4–2. LAR have taken 4 of the last 6 but have yet to win at home in the series — 4 of the 6 landed inside a score.

Injury report: 18 players out and 25 questionable across the two teams — Puka Nacua (LAR WR, Out), C.J. West (SF DT, IR, designated to return), Davante Adams (LAR WR, Injured reserve) and Gracen Halton (SF DT, Injured reserve).

All Rams v 49ers games

Los Angeles Rams vs San Francisco 49ers: team comparison (2026 season, NFL rank in brackets)
Los Angeles RamsSan Francisco 49ers
Record5-47-1
Division2nd NFC W1st NFC W
Last six resultsW L L W W WW W W W L W
Points / G23.8 (13th)29.4 (3rd)
Total Yds / G390.6 (5th)382.8 (7th)
Yards / Play5.8 (9th)6.4 (1st)
Pass Yds / G265.2 (7th)247.5 (14th)
Rush Yds / G125.3 (9th)135.3 (7th)
3rd Down %40% (13th)51.7% (2nd)
1st Downs / G23.1 (3rd)22.0 (6th)
Turnover Diff-4 (25th)+1 (13th)
Pts Allowed / G20.1 (8th)19.5 (6th)
Yds Allowed / G312.9 (5th)303.8 (2nd)
Pass Yds Allowed209.1 (4th)222.9 (9th)
Rush Yds Allowed103.8 (14th)80.9 (2nd)
Sacks16 (24th)15 (28th)
  • Los Angeles Rams stats, schedule and roster
  • San Francisco 49ers stats, schedule and roster
Los Angeles Rams vs San Francisco 49ers injury report
PlayerTeamPositionStatusInjury
Puka NacuaLARWROutKnee
Trent McDuffieLARCBQuestionableBack
Kam CurlLARSQuestionableToe
C.J. WestSFDTIR, designated to returnKnee
Deommodore LenoirSFCBQuestionableFoot
Renardo GreenSFCBQuestionableBack
Myles GarrettLARDEQuestionableKnee
Davis AllenLARTEQuestionableOblique
Deebo Samuel Sr.SFWRQuestionableHamstring
Mike EvansSFWRQuestionableAchilles
Siran NealSFSQuestionableKnee
Upton StoutSFCBQuestionableShoulder
Colby ParkinsonLARTEQuestionableRibs
Davante AdamsLARWRInjured reserveNot injury related - resting player
Gracen HaltonSFDTInjured reserveQuadricep
Jordan WhittingtonLARWRInjured reserveBack
Joe CardonaLARLSQuestionableAnkle
Terrance FergusonLARTEIR, designated to returnAnkle
Steve AvilaLARGQuestionableHamstring
Brandon AiyukSFWROutPersonal
Nate HobbsSFCBIR, designated to returnGroin
Christian KirkSFWRInjured reserveKnee
Jaylen WatsonLARCBInjured reserveShoulder
Dean ConnorsLARRBInjured reserveHand
De'Zhaun StriblingSFWRInjured reserveAnkle
Keir Thomas IILARLBQuestionableGroin
Kobie TurnerLARDEInjured reserveGroin
Poona FordLARDTInjured reserveNot injury related - resting player
Brett TothSFCQuestionableConcussion
Blake GrupeLARPKInjured reserve
Nick MartinSFLBInjured reserveHamstring
Jake TongesSFTEInjured reserveKnee
Alfred CollinsSFDTInjured reserveKnee
Sam OkuayinonuSFDTInjured reserve
Zech McPhearsonLARCBQuestionable
Nick ZakeljSFOTInjured reserveUndisclosed
Austen PleasantsSFOTIR, designated to returnKnee
Justin DedichLARGIR, designated to returnUndisclosed
Isaac GuerendoSFRBReserve/PUPPectoral
Matthew CaldwellLARQBInjured reserveUndisclosed
Daniel RickertLARDEInjured reserveKnee
Ricky PearsallSFWRInjured reserve
Mikail KamaraSFDEInjured reserve
Andrew Farmer IISFDEInjured reserveBack
Eddie Walls IIILARLBInjured reserve
Darrick ForrestSFSInjured reserveUndisclosed
Rob HavensteinLAROTInjured Reserve
Alex JohnsonLARCBInjured Reserve
Ahkello WitherspoonLARCBInjured Reserve
Mario WilliamsLARWRInjured Reserve
Kamren KinchensLARSQuestionable
CJ DanielsLARWROut
Robert JonesSFGQuestionable
Patrick Taylor Jr.SFRBInjured Reserve
Trent TaylorSFWRInjured Reserve
Tre TomlinsonSFCBQuestionable
William Bradley-KingSFDEInjured Reserve
Tarron JacksonSFDEInjured Reserve
Tanner McLachlanSFTEInjured Reserve
Titus LeoSFDEInjured Reserve
Xavier ThomasSFLBInjured Reserve
Naquan JonesSFDTOut
Malik MustaphaSFSQuestionable
Dre GreenlawSFLBQuestionable
Luke GiffordSFLBQuestionable
Mykel WilliamsSFDEOut
Nick BosaSFDEQuestionable
Demarcus RobinsonSFWRInjured Reserve
Romello HeightSFDEQuestionable
KhaDarel HodgeSFWRQuestionable
Victor DimukejeSFDEInjured Reserve

LAR have taken 4 of the last 6 but have yet to win at home in the series — 4 of the 6 landed inside a score.

Recent meetings
GameWinnerScoreVenue
2026 Week 1SF27–7Melbourne Cricket Ground
2025 Week 10LAR42–26Levi's Stadium
2025 Week 5SF26–23SoFi Stadium
2024 Week 15LAR12–6Levi's Stadium
2024 Week 3LAR27–24SoFi Stadium
2023 Week 18LAR21–20Levi's Stadium

Frequently asked questions

When do the Rams play the 49ers?

Los Angeles Rams at San Francisco 49ers is Week 14 of the 2026 NFL season, kicking off on Sunday, December 13 at 4:25 PM ET at Levi's Stadium.

What is the head-to-head record between the Rams and the 49ers?

The recent series is LAR 4–2 over the last 6 meetings — the last one finished SF 27–7 in 2026 (Week 1), and against the spread the series is LAR 4–2.

Who is injured for Rams vs 49ers?

71 players carry a designation: 18 out and 25 questionable, including Puka Nacua (LAR WR, Out), C.J. West (SF DT, IR, designated to return), Davante Adams (LAR WR, Injured reserve) and Gracen Halton (SF DT, Injured reserve).

Rams v 49ers: teams and standings

  • Los Angeles Rams
  • Los Angeles Rams Stats
  • San Francisco 49ers
  • San Francisco 49ers Stats
  • NFC West Standings
  • NFC Standings
  • NFL Power Rankings this week

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