49ers vs Rams: head to head

Frequently asked questions

Who leads the 49ers vs Rams series?

The 49ers lead 11-7 over the 18 games since 2018.

When did the 49ers last play the Rams?

10 September 2026, in Week 1 of the 2026 season: the 49ers won 27-7 at Melbourne Cricket Ground.

What is the average score when the 49ers play the Rams?

45.8 points a game: the 49ers average 24 and the Rams 21.8 in their 18 meetings since 2018.

What is the biggest win in the 49ers vs Rams series?

The Rams won by 29, 39-10, in Week 7 of 2018.

When do the 49ers play the Rams next?

Sunday 13 December 2026, 4:25 PM ET, in Week 14: the Rams at the 49ers, Levi's Stadium.