Seattle Seahawks vs San Francisco 49ers Prediction, Odds & Props — Week 12

The Seattle Seahawks visit the San Francisco 49ers in Week 12 of the 2026 NFL season, on Sunday, November 29 at 4:25 PM ET at Levi's Stadium. Open air · Grass. The Seahawks are 5-4 (3rd in the NFC West), the 49ers 7-1 (1st in the NFC West). The Seahawks went 3-3 down the stretch, the 49ers 5-1.

In 2026 the Seahawks scored 22.4 points per game (18th in the NFL) and allowed 18 (4th in the NFL); the 49ers scored 29.4 (3rd in the NFL) and allowed 19.5 (6th in the NFL).

Head-to-head, the recent series reads SF 3–3 over the last 6 meetings, at an average total of 41.8; against the spread it is SF 3–3, and the total has gone OVER 3–3. The last 6 meetings are split 3–3 but have yet to win at home in the series — 3 of the 6 landed inside a score.

Injury report: 22 players out and 24 questionable across the two teams — Gracen Halton (SF DT, Injured reserve), Charles Cross (SEA OT, Doubtful), Sam Darnold (SEA QB, Out) and Quenton Nelson (SEA G, Doubtful).

All Seahawks v 49ers games

Seattle Seahawks vs San Francisco 49ers: team comparison (2026 season, NFL rank in brackets)
Seattle SeahawksSan Francisco 49ers
Record5-47-1
Division3rd NFC W1st NFC W
Last six resultsW L L W L WW W W W L W
Points / G22.4 (18th)29.4 (3rd)
Total Yds / G342.9 (17th)382.8 (7th)
Yards / Play5.5 (20th)6.4 (1st)
Pass Yds / G232.1 (19th)247.5 (14th)
Rush Yds / G110.8 (18th)135.3 (7th)
3rd Down %37.4% (20th)51.7% (2nd)
1st Downs / G20.4 (12th)22.0 (6th)
Turnover Diff-1 (18th)+1 (13th)
Pts Allowed / G18 (4th)19.5 (6th)
Yds Allowed / G257.9 (1st)303.8 (2nd)
Pass Yds Allowed168.8 (1st)222.9 (9th)
Rush Yds Allowed89.1 (4th)80.9 (2nd)
Sacks21 (13th)15 (28th)
  • Seattle Seahawks stats, schedule and roster
  • San Francisco 49ers stats, schedule and roster
Seattle Seahawks vs San Francisco 49ers injury report
PlayerTeamPositionStatusInjury
Gracen HaltonSFDTInjured reserveQuadricep
Mike EvansSFWRQuestionableRibs
Deebo Samuel Sr.SFWRQuestionableHamstring
Rashid ShaheedSEAWRQuestionableKnee
Charles CrossSEAOTDoubtfulAnkle
Uchenna NwosuSEALBQuestionableAnkle
Brandon PiliSEADTQuestionableBack
Leonard WilliamsSEADTQuestionableStinger
Sam DarnoldSEAQBOutQuadricep
Quenton NelsonSEAGDoubtfulKnee
C.J. WestSFDTInjured reserveUndisclosed
Deommodore LenoirSFCBQuestionableFoot
Renardo GreenSFCBQuestionableHamstring
Brandon AiyukSFWROutPersonal
Drew LockSEAQBQuestionableElbow
Nate HobbsSFCBIR, designated to returnGroin
Christian KirkSFWRInjured reserveKnee
De'Zhaun StriblingSFWRInjured reserveAnkle
Elijah ArroyoSEATEInjured reserveShoulder
Brett TothSFCQuestionableConcussion
Nick MartinSFLBInjured reserveHamstring
Julian NealSEACBInjured reserveHamstring
Jacardia WrightSEARBOutFoot
Jake TongesSFTEInjured reserveKnee
Alfred CollinsSFDTInjured reserveKnee
Sam OkuayinonuSFDTInjured reserve
Nick ZakeljSFOTInjured reserveUndisclosed
Austen PleasantsSFOTIR, designated to returnKnee
Isaac GuerendoSFRBReserve/PUPPectoral
Terrion ArnoldSEACBOut
Mason RichmanSEAGInjured reserveLeg
Bud ClarkSEASInjured reserve
Jake BoboSEAWRInjured reserveKnee
Robbie OuztsSEAFBInjured reserve
Ricky PearsallSFWRInjured reserve
Mikail KamaraSFDEInjured reserve
Andrew Farmer IISFDEInjured reserveBack
Darrick ForrestSFSInjured reserveUndisclosed
Bryce CabeldueSEAGInjured Reserve
Kenny McIntoshSEARBQuestionable
Chris Paul Jr.SEALBInjured Reserve
Ja'Markis WestonSEALBInjured Reserve
Joseph VaughnSEALBQuestionable
Brock LampeSEAFBQuestionable
Power EcholsSEALBInjured Reserve
Aaron SmithSEALBInjured Reserve
Velus Jones Jr.SEARBQuestionable
Chazz SurrattSEALBInjured Reserve
Tyrice KnightSEALBQuestionable
Jadarian PriceSEARBInjured Reserve
Robert JonesSFGQuestionable
Patrick Taylor Jr.SFRBInjured Reserve
Trent TaylorSFWRInjured Reserve
Tre TomlinsonSFCBQuestionable
William Bradley-KingSFDEInjured Reserve
Tarron JacksonSFDEInjured Reserve
Tanner McLachlanSFTEInjured Reserve
Titus LeoSFDEInjured Reserve
Xavier ThomasSFLBInjured Reserve
Naquan JonesSFDTOut
Malik MustaphaSFSQuestionable
Dre GreenlawSFLBQuestionable
Luke GiffordSFLBQuestionable
Mykel WilliamsSFDEOut
Nick BosaSFDEQuestionable
Siran NealSFSQuestionable
Demarcus RobinsonSFWRInjured Reserve
Romello HeightSFDEQuestionable
KhaDarel HodgeSFWRQuestionable
Victor DimukejeSFDEInjured Reserve

The last 6 meetings are split 3–3 but have yet to win at home in the series — 3 of the 6 landed inside a score.

Recent meetings
GameWinnerScoreVenue
2026 Week 5SF32–29Lumen Field
2025 DIVSEA41–6Lumen Field
2025 Week 18SEA13–3Levi's Stadium
2025 Week 1SF17–13Lumen Field
2024 Week 11SEA20–17Levi's Stadium
2024 Week 6SF36–24Lumen Field

Frequently asked questions

When do the Seahawks play the 49ers?

Seattle Seahawks at San Francisco 49ers is Week 12 of the 2026 NFL season, kicking off on Sunday, November 29 at 4:25 PM ET at Levi's Stadium.

What is the head-to-head record between the Seahawks and the 49ers?

The recent series is SF 3–3 over the last 6 meetings — the last one finished SF 32–29 in 2026 (Week 5), and against the spread the series is SF 3–3.

Who is injured for Seahawks vs 49ers?

70 players carry a designation: 22 out and 24 questionable, including Gracen Halton (SF DT, Injured reserve), Charles Cross (SEA OT, Doubtful), Sam Darnold (SEA QB, Out) and Quenton Nelson (SEA G, Doubtful).

Seahawks v 49ers: teams and standings

  • Seattle Seahawks
  • Seattle Seahawks Stats
  • San Francisco 49ers
  • San Francisco 49ers Stats
  • NFC West Standings
  • NFC Standings
  • NFL Power Rankings this week

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