The Arizona Cardinals visit the San Francisco 49ers in Week 3 of the 2026 NFL season, on Sunday, September 27 at 4:05 PM ET at Levi's Stadium. Open air · Grass. The Cardinals are 1-1 (4th in the NFC West), the 49ers 2-0 (1st in the NFC West). The Cardinals went 1-5 down the stretch, the 49ers 4-2.
The Statz model projects ARI 18, SF 27: the San Francisco 49ers by 8.8 — a 74% win probability. The market closes at SF -7.5 with a total of 48.5, against the model's 45.5. Spread lean: SF −7.5, +3.9pp against the market.
In 2026 the Cardinals scored 16.5 points per game (25th in the NFL) and allowed 22.5 (14th in the NFL); the 49ers scored 31 (4th in the NFL) and allowed 10 (3rd in the NFL).
Head-to-head, the recent series reads SF 4–2 over the last 6 meetings, at an average total of 56.2; against the spread it is SF 3–3, and the total has gone OVER 4–2. SF have taken 4 of the last 6 — 2 of the 6 landed inside a score.
Injury report: 22 players out and 30 questionable across the two teams — Demarcus Robinson (SF WR, Injured reserve), James Thompson Jr. (SF DT, Out), Dadrion Taylor-Demerson (ARI S, Out) and Romello Height (SF DE, Out).
Best price across 8 sportsbooks: ARI +344 at Kalshi and SF -326 at Polymarket on the moneyline, the spread SF -7.5 (+106) and the total 48.5 (over +102). The Props tab prices 56 player props for this game — passing, rushing and receiving yards, receptions and anytime touchdown markets — at Bet365's lines.
Frequently asked questions
When do the Cardinals play the 49ers?
Arizona Cardinals at San Francisco 49ers is Week 3 of the 2026 NFL season, kicking off on Sunday, September 27 at 4:05 PM ET at Levi's Stadium.
Who is favoured, the Cardinals or the 49ers?
The market makes it SF -7.5. The Statz model has the San Francisco 49ers by 8.8 (SF -8.8) — a 74% win probability.
What is the projected score for Cardinals vs 49ers?
The Statz model projects Arizona Cardinals 18, San Francisco 49ers 27 — a total of 45.5 against a market total of 48.5.
What is the head-to-head record between the Cardinals and the 49ers?
The recent series is SF 4–2 over the last 6 meetings — the last one finished SF 41–22 in 2025 (Week 11), and against the spread the series is SF 3–3.
Who is injured for Cardinals vs 49ers?
90 players carry a designation: 22 out and 30 questionable, including Demarcus Robinson (SF WR, Injured reserve), James Thompson Jr. (SF DT, Out), Dadrion Taylor-Demerson (ARI S, Out) and Romello Height (SF DE, Out). The report refreshes with the data sync before game days and the model prices designations in automatically.
What are the odds for Cardinals vs 49ers?
The best prices on Statz NFL are ARI +344 at Kalshi and SF -326 at Polymarket on the moneyline, the spread SF -7.5 (+106) and the total 48.5 (over +102), compared across 8 sportsbooks. Every price links out to the book.
Which player props are available for Cardinals vs 49ers?
56 player props for this game — passing, rushing and receiving yards, receptions and anytime touchdown markets at Bet365's lines. The Statz model projects every one and rates it at the quoted price; the ratings are part of NFL Pro.