The San Francisco 49ers visit the Seattle Seahawks in Week 5 of the 2026 NFL season, on Sunday, October 11 at 4:25 PM ET at Lumen Field. Open air · Fieldturf. The 49ers are 2-0 (1st in the NFC West), the Seahawks 2-0 (2nd in the NFC West). The 49ers went 4-2 down the stretch, the Seahawks 5-1.
In 2026 the 49ers scored 31 points per game (4th in the NFL) and allowed 10 (3rd in the NFL); the Seahawks scored 22 (17th in the NFL) and allowed 8.5 (2nd in the NFL).
Head-to-head, the recent series reads SEA 3–3 over the last 6 meetings, at an average total of 39; against the spread it is SEA 4–2, and the total has gone UNDER 4–2. The last 6 meetings are split 3–3 — 2 of the 6 landed inside a score.
Injury report: 20 players out and 30 questionable across the two teams — Demarcus Robinson (SF WR, Injured reserve), James Thompson Jr. (SF DT, Out), Ty Okada (SEA S, Out) and Julian Love (SEA S, Out).
Frequently asked questions
When do the 49ers play the Seahawks?
San Francisco 49ers at Seattle Seahawks is Week 5 of the 2026 NFL season, kicking off on Sunday, October 11 at 4:25 PM ET at Lumen Field.
What is the head-to-head record between the 49ers and the Seahawks?
The recent series is SEA 3–3 over the last 6 meetings — the last one finished SEA 41–6 in 2025 (DIV), and against the spread the series is SEA 4–2.
Who is injured for 49ers vs Seahawks?
88 players carry a designation: 20 out and 30 questionable, including Demarcus Robinson (SF WR, Injured reserve), James Thompson Jr. (SF DT, Out), Ty Okada (SEA S, Out) and Julian Love (SEA S, Out). The report refreshes with the data sync before game days and the model prices designations in automatically.