The San Francisco 49ers visit the Los Angeles Chargers in Week 15 of the 2026 NFL season, on Thursday, December 17 at 8:15 PM ET at SoFi Stadium. Dome · Matrixturf. The 49ers are 2-0 (1st in the NFC West), the Chargers 0-2 (4th in the AFC West). The 49ers went 4-2 down the stretch, the Chargers 0-6.
In 2026 the 49ers scored 31 points per game (4th in the NFL) and allowed 10 (3rd in the NFL); the Chargers scored 14 (30th in the NFL) and allowed 26 (22nd in the NFL).
Head-to-head, the recent series reads LAC 1–1 over the last 2 meetings, at an average total of 47; against the spread it is LAC 1–1, and the total has gone OVER 1–1. The last 2 meetings are split 1–1 — 2 of the 2 landed inside a score.
Injury report: 22 players out and 27 questionable across the two teams — Trey Pipkins III (LAC OT, Injured reserve), Demarcus Robinson (SF WR, Injured reserve), James Thompson Jr. (SF DT, Out) and Kayode Awosika (LAC G, Out).
Frequently asked questions
When do the 49ers play the Chargers?
San Francisco 49ers at Los Angeles Chargers is Week 15 of the 2026 NFL season, kicking off on Thursday, December 17 at 8:15 PM ET at SoFi Stadium.
What is the head-to-head record between the 49ers and the Chargers?
The recent series is LAC 1–1 over the last 2 meetings — the last one finished SF 22–16 in 2022 (Week 10), and against the spread the series is LAC 1–1.
Who is injured for 49ers vs Chargers?
87 players carry a designation: 22 out and 27 questionable, including Trey Pipkins III (LAC OT, Injured reserve), Demarcus Robinson (SF WR, Injured reserve), James Thompson Jr. (SF DT, Out) and Kayode Awosika (LAC G, Out). The report refreshes with the data sync before game days and the model prices designations in automatically.