The San Francisco 49ers visit the Los Angeles Chargers in Week 15 of the 2026 NFL season, on Thursday, December 17 at 8:15 PM ET at SoFi Stadium. Dome · Matrixturf. The 49ers are 7-1 (1st in the NFC West), the Chargers 0-8 (4th in the AFC West). The 49ers went 5-1 down the stretch, the Chargers 0-6.
In 2026 the 49ers scored 29.4 points per game (3rd in the NFL) and allowed 19.5 (6th in the NFL); the Chargers scored 15.1 (32nd in the NFL) and allowed 27.4 (28th in the NFL).
Head-to-head, the recent series reads LAC 1–1 over the last 2 meetings, at an average total of 47; against the spread it is LAC 1–1, and the total has gone OVER 1–1. The last 2 meetings are split 1–1 — 2 of the 2 landed inside a score.
Injury report: 21 players out and 24 questionable across the two teams — Gracen Halton (SF DT, Injured reserve), C.J. West (SF DT, Injured reserve), Brandon Aiyuk (SF WR, Out) and Denzel Perryman (LAC LB, IR, designated to return).
| San Francisco 49ers | Los Angeles Chargers | |
|---|---|---|
| Record | 7-1 | 0-8 |
| Division | 1st NFC W | 4th AFC W |
| Last six results | W W W W L W | L L L L L L |
| Points / G | 29.4 (3rd) | 15.1 (32nd) |
| Total Yds / G | 382.8 (7th) | 316.4 (26th) |
| Yards / Play | 6.4 (1st) | 5.1 (26th) |
| Pass Yds / G | 247.5 (14th) | 201.9 (24th) |
| Rush Yds / G | 135.3 (7th) | 114.5 (16th) |
| 3rd Down % | 51.7% (2nd) | 34.2% (28th) |
| 1st Downs / G | 22.0 (6th) | 16.4 (28th) |
| Turnover Diff | +1 (13th) | -7 (29th) |
| Pts Allowed / G | 19.5 (6th) | 27.4 (28th) |
| Yds Allowed / G | 303.8 (2nd) | 352.6 (18th) |
| Pass Yds Allowed | 222.9 (9th) | 230.6 (12th) |
| Rush Yds Allowed | 80.9 (2nd) | 122 (20th) |
| Sacks | 15 (28th) | 13 (30th) |
| Player | Team | Position | Status | Injury |
|---|---|---|---|---|
| Gracen Halton | SF | DT | Injured reserve | Quadricep |
| Mike Evans | SF | WR | Questionable | Ribs |
| Justin Herbert | LAC | QB | Questionable | |
| Kayode Awosika | LAC | G | Questionable | Fibula |
| Deebo Samuel Sr. | SF | WR | Questionable | Hamstring |
| Brenen Thompson | LAC | WR | Questionable | Quadricep |
| Deane Leonard | LAC | CB | Questionable | Concussion |
| Kendall Williamson | LAC | S | Questionable | Calf |
| C.J. West | SF | DT | Injured reserve | Undisclosed |
| Deommodore Lenoir | SF | CB | Questionable | Foot |
| Renardo Green | SF | CB | Questionable | Hamstring |
| Ladd McConkey | LAC | WR | Questionable | Concussion |
| Brandon Aiyuk | SF | WR | Out | Personal |
| Isas Waxter | LAC | CB | Questionable | Ankle |
| Justin Eboigbe | LAC | DT | Questionable | Shoulder |
| Denzel Perryman | LAC | LB | IR, designated to return | Pectoral |
| David Njoku | LAC | TE | IR, designated to return | Fibula |
| Nate Hobbs | SF | CB | IR, designated to return | Groin |
| Christian Kirk | SF | WR | Injured reserve | Knee |
| De'Zhaun Stribling | SF | WR | Injured reserve | Ankle |
| Derwin James Jr. | LAC | S | Injured reserve | Hamstring |
| Brett Toth | SF | C | Questionable | Concussion |
| Alec Ingold | LAC | FB | Injured reserve | Shoulder |
| Nick Martin | SF | LB | Injured reserve | Hamstring |
| Trevor Penning | LAC | G | Injured reserve | Concussion |
| Trey Lance | LAC | QB | Injured reserve | Groin |
| Rashawn Slater | LAC | OT | Injured reserve | Ankle |
| Trey Pipkins III | LAC | OT | Injured reserve | Knee |
| Jake Tonges | SF | TE | Injured reserve | Knee |
| Alfred Collins | SF | DT | Injured reserve | Knee |
| Isaiah World | LAC | OT | Out | |
| Sam Okuayinonu | SF | DT | Injured reserve | |
| Nick Zakelj | SF | OT | Injured reserve | Undisclosed |
| Austen Pleasants | SF | OT | IR, designated to return | Knee |
| Isaac Guerendo | SF | RB | Reserve/PUP | Pectoral |
| Tyler Biadasz | LAC | C | Injured reserve | Knee |
| Ricky Pearsall | SF | WR | Injured reserve | |
| Mikail Kamara | SF | DE | Injured reserve | |
| Andrew Farmer II | SF | DE | Injured reserve | Back |
| Darrick Forrest | SF | S | Injured reserve | Undisclosed |
| Austin Deculus | LAC | OT | Questionable | |
| Jordan Oladokun | LAC | CB | Injured Reserve | |
| Josh Fuga | LAC | DT | Injured Reserve | |
| Kyle Kennard | LAC | LB | Injured Reserve | |
| Dalevon Campbell | LAC | WR | Injured Reserve | |
| Luke Grimm | LAC | WR | Injured Reserve | |
| KeAndre Lambert-Smith | LAC | WR | Injured Reserve | |
| Bud Dupree | LAC | LB | Questionable | |
| Sincere Brown | LAC | WR | Injured Reserve | |
| Theo Wease Jr. | LAC | WR | Out | |
| Robert Jones | SF | G | Questionable | |
| Patrick Taylor Jr. | SF | RB | Injured Reserve | |
| Trent Taylor | SF | WR | Injured Reserve | |
| Tre Tomlinson | SF | CB | Questionable | |
| William Bradley-King | SF | DE | Injured Reserve | |
| Tarron Jackson | SF | DE | Injured Reserve | |
| Tanner McLachlan | SF | TE | Injured Reserve | |
| Titus Leo | SF | DE | Injured Reserve | |
| Xavier Thomas | SF | LB | Injured Reserve | |
| Naquan Jones | SF | DT | Out | |
| Malik Mustapha | SF | S | Questionable | |
| Dre Greenlaw | SF | LB | Questionable | |
| Luke Gifford | SF | LB | Questionable | |
| Mykel Williams | SF | DE | Out | |
| Nick Bosa | SF | DE | Questionable | |
| Siran Neal | SF | S | Questionable | |
| Demarcus Robinson | SF | WR | Injured Reserve | |
| Romello Height | SF | DE | Questionable | |
| KhaDarel Hodge | SF | WR | Questionable | |
| Victor Dimukeje | SF | DE | Injured Reserve |
The last 2 meetings are split 1–1 — 2 of the 2 landed inside a score.
| Game | Winner | Score | Venue |
|---|---|---|---|
| 2022 Week 10 | SF | 22–16 | Levi's Stadium |
| 2018 Week 4 | LAC | 29–27 | Dignity Health Sports Park |