The San Francisco 49ers have 26 players on the injury report ahead of Week 10 at the Cowboys: 19 out or on a reserve list, 0 doubtful and 7 questionable.
| Player | Position | Status | Practice | Injury |
|---|---|---|---|---|
| C.J. West | DT | IR-R | Limited | Knee |
| Gracen Halton | DT | IR | Quadricep | |
| Brandon Aiyuk | WR | OUT | Personal | |
| Nate Hobbs | CB | IR-R | Full | Groin |
| Christian Kirk | WR | IR | Knee | |
| Brian Robinson Jr. | RB | IR | Hamstring | |
| De'Zhaun Stribling | WR | IR | Ankle | |
| Kalia Davis | DT | IR | Quadricep | |
| Nick Martin | LB | IR | Hamstring | |
| Jake Tonges | TE | IR | Knee | |
| Alfred Collins | DT | IR | Knee | |
| Sam Okuayinonu | DT | IR | ||
| Nick Zakelj | OT | IR | Undisclosed | |
| Austen Pleasants | OT | IR-R | Knee | |
| Isaac Guerendo | RB | PUP-R | Pectoral | |
| Ricky Pearsall | WR | IR | ||
| Mikail Kamara | DE | IR | ||
| Andrew Farmer II | DE | IR | Back | |
| Darrick Forrest | S | IR | Undisclosed | |
| Deommodore Lenoir | CB | QUES | DNP | Foot |
| Renardo Green | CB | QUES | DNP | Back |
| Mike Evans | WR | QUES | DNP | Achilles |
| Deebo Samuel Sr. | WR | QUES | Limited | Hamstring |
| Upton Stout | CB | QUES | Limited | Shoulder |
| Siran Neal | S | QUES | Limited | Knee |
| Brett Toth | C | QUES | Concussion |