San Francisco 49ers vs New York Giants Prediction, Odds & Props — Week 13

The San Francisco 49ers visit the New York Giants in Week 13 of the 2026 NFL season, on Sunday, December 6 at 1:00 PM ET at MetLife Stadium. Open air · Fieldturf. The 49ers are 7-1 (1st in the NFC West), the Giants 5-2-1 (1st in the NFC East). The 49ers went 5-1 down the stretch, the Giants 4-1.

In 2026 the 49ers scored 29.4 points per game (3rd in the NFL) and allowed 19.5 (6th in the NFL); the Giants scored 22.8 (16th in the NFL) and allowed 21.5 (12th in the NFL).

Head-to-head, the recent series reads SF 3–1 over the last 4 meetings, at an average total of 48.8; against the spread it is SF 3–1, and the total has gone OVER 3–1. SF have taken 3 of the last 4 but have yet to win at home in the series — 1 of the 4 landed inside a score.

Injury report: 17 players out and 24 questionable across the two teams — Gracen Halton (SF DT, Injured reserve), Cam Skattebo (NYG RB, Out), C.J. West (SF DT, Injured reserve) and Brandon Aiyuk (SF WR, Out).

All 49ers v Giants games

San Francisco 49ers vs New York Giants: team comparison (2026 season, NFL rank in brackets)
San Francisco 49ersNew York Giants
Record7-15-2-1
Division1st NFC W1st NFC E
Last six resultsW W W W L WW W T L W W
Points / G29.4 (3rd)22.8 (16th)
Total Yds / G382.8 (7th)349.6 (15th)
Yards / Play6.4 (1st)5.3 (23rd)
Pass Yds / G247.5 (14th)237.5 (16th)
Rush Yds / G135.3 (7th)112.1 (17th)
3rd Down %51.7% (2nd)40.4% (12th)
1st Downs / G22.0 (6th)20.3 (14th)
Turnover Diff+1 (13th)-2 (23rd)
Pts Allowed / G19.5 (6th)21.5 (12th)
Yds Allowed / G303.8 (2nd)312.9 (6th)
Pass Yds Allowed222.9 (9th)189.3 (3rd)
Rush Yds Allowed80.9 (2nd)123.6 (21st)
Sacks15 (28th)16 (27th)
  • San Francisco 49ers stats, schedule and roster
  • New York Giants stats, schedule and roster
San Francisco 49ers vs New York Giants injury report
PlayerTeamPositionStatusInjury
Gracen HaltonSFDTInjured reserveQuadricep
Colton HoodNYGCBQuestionableFinger
J.J. McCarthyNYGQBQuestionableHip
Cam SkatteboNYGRBOutHamstring
Mike EvansSFWRQuestionableRibs
Deebo Samuel Sr.SFWRQuestionableHamstring
C.J. WestSFDTInjured reserveUndisclosed
Deommodore LenoirSFCBQuestionableFoot
Renardo GreenSFCBQuestionableHamstring
Abdul CarterNYGLBQuestionableKnee
Malik HarrisonNYGLBQuestionableGroin
Brandon AiyukSFWROutPersonal
Nate HobbsSFCBIR, designated to returnGroin
Christian KirkSFWRInjured reserveKnee
De'Zhaun StriblingSFWRInjured reserveAnkle
Tyrone Tracy Jr.NYGRBInjured reserveKnee
Tremaine EdmundsNYGLBInjured reserveShoulder
Brett TothSFCQuestionableConcussion
Braxton BerriosNYGWRInjured reserveFoot
Nick MartinSFLBInjured reserveHamstring
Chauncey GolstonNYGDEInjured reserveNeck
Jaxson DartNYGQBInjured reserveKnee
Brian BurnsNYGLBInjured reserveAnkle
Jake TongesSFTEInjured reserveKnee
Alfred CollinsSFDTInjured reserveKnee
Roy Robertson-HarrisNYGDTInjured reserve
Sam OkuayinonuSFDTInjured reserve
DJ JamesNYGCBQuestionableUndisclosed
Nick ZakeljSFOTInjured reserveUndisclosed
Austen PleasantsSFOTIR, designated to returnKnee
Korie BlackNYGCBIR, designated to returnUndisclosed
Isaac GuerendoSFRBReserve/PUPPectoral
Calvin Austin IIINYGWRInjured reserveKnee
Jarrick Bernard-ConverseNYGCBInjured reserve
Ricky PearsallSFWRInjured reserve
Mikail KamaraSFDEInjured reserve
Andrew Farmer IISFDEInjured reserveBack
Rico PaytonNYGCBInjured reserveUndisclosed
Gunner OlszewskiNYGWRInjured reserveAchilles
Darrick ForrestSFSInjured reserveUndisclosed
Thaddeus DixonNYGCBInjured reserve
Dante MillerNYGRBInjured Reserve
Rakeem Nunez-RochesNYGDTInjured Reserve
Chris BoardNYGLBInjured Reserve
TJ MooreNYGCBQuestionable
Wan'Dale RobinsonNYGWRInjured Reserve
Lucas PatrickNYGGQuestionable
C.J. RavenellNYGDEQuestionable
Beaux CollinsNYGWRQuestionable
Jalin HyattNYGWRQuestionable
Robert JonesSFGQuestionable
Patrick Taylor Jr.SFRBInjured Reserve
Trent TaylorSFWRInjured Reserve
Tre TomlinsonSFCBQuestionable
William Bradley-KingSFDEInjured Reserve
Tarron JacksonSFDEInjured Reserve
Tanner McLachlanSFTEInjured Reserve
Titus LeoSFDEInjured Reserve
Xavier ThomasSFLBInjured Reserve
Naquan JonesSFDTOut
Malik MustaphaSFSQuestionable
Dre GreenlawSFLBQuestionable
Luke GiffordSFLBQuestionable
Mykel WilliamsSFDEOut
Nick BosaSFDEQuestionable
Siran NealSFSQuestionable
Demarcus RobinsonSFWRInjured Reserve
Romello HeightSFDEQuestionable
KhaDarel HodgeSFWRQuestionable
Victor DimukejeSFDEInjured Reserve

SF have taken 3 of the last 4 but have yet to win at home in the series — 1 of the 4 landed inside a score.

Recent meetings
GameWinnerScoreVenue
2025 Week 9SF34–24MetLife Stadium
2023 Week 3SF30–12Levi's Stadium
2020 Week 3SF36–9MetLife Stadium
2018 Week 10NYG27–23Levi's Stadium

Frequently asked questions

When do the 49ers play the Giants?

San Francisco 49ers at New York Giants is Week 13 of the 2026 NFL season, kicking off on Sunday, December 6 at 1:00 PM ET at MetLife Stadium.

What is the head-to-head record between the 49ers and the Giants?

The recent series is SF 3–1 over the last 4 meetings — the last one finished SF 34–24 in 2025 (Week 9), and against the spread the series is SF 3–1.

Who is injured for 49ers vs Giants?

70 players carry a designation: 17 out and 24 questionable, including Gracen Halton (SF DT, Injured reserve), Cam Skattebo (NYG RB, Out), C.J. West (SF DT, Injured reserve) and Brandon Aiyuk (SF WR, Out).

49ers v Giants: teams and standings

  • San Francisco 49ers
  • San Francisco 49ers Stats
  • New York Giants
  • New York Giants Stats
  • NFC West Standings
  • NFC Standings
  • NFC East Standings
  • NFL Power Rankings this week

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