The Buffalo Bills play 17 regular-season games in 2026 — 8 at home and 9 on the road, with their bye in Week 7. They open at the Texans on Sunday, September 13.
They have 5 primetime games: Week 2 against the Lions (TNF), Week 5 at the Rams (MNF), Week 9 at the Vikings (MNF), Week 12 against the Chiefs (TNF) and Week 14 at the Packers (SNF).
Through Week 5 the Buffalo Bills are 4-1 — 2-1 at home and 2-0 on the road.
The Statz season simulation projects 12 wins (a 9–14 win range) and a 89.8% chance of making the playoffs.
| Week | Date | Opponent | Result or kickoff |
|---|---|---|---|
| Week 1 | SUN 9/13 | at Houston Texans | W 36–31 |
| Week 2 | THU 9/17 | vs Detroit Lions | W 41–31 |
| Week 3 | SUN 9/27 | vs Los Angeles Chargers | W 24–16 |
| Week 4 | SUN 10/4 | vs New England Patriots | L 26–29 |
| Week 5 | MON 10/12 | at Los Angeles Rams | W 37–34 |
| Week 6 | SUN 10/18 | at Las Vegas Raiders | 4:25 PM ET |
| Week 7 | Bye week | ||
| Week 8 | SUN 11/1 | vs Baltimore Ravens | 1:00 PM ET |
| Week 9 | MON 11/9 | at Minnesota Vikings | 8:15 PM ET |
| Week 10 | SUN 11/15 | at New York Jets | 1:00 PM ET |
| Week 11 | SUN 11/22 | vs Miami Dolphins | 1:00 PM ET |
| Week 12 | THU 11/26 | vs Kansas City Chiefs | 8:20 PM ET |
| Week 13 | SUN 12/6 | at New England Patriots | 4:25 PM ET |
| Week 14 | SUN 12/13 | at Green Bay Packers | 8:20 PM ET |
| Week 15 | SAT 12/19 | vs Chicago Bears | 8:20 PM ET |
| Week 16 | FRI 12/25 | at Denver Broncos | 4:30 PM ET |
| Week 17 | SUN 1/3 | at Miami Dolphins | 1:00 PM ET |
| Week 18 | SUN 1/10 | vs New York Jets | Time TBD |