The Buffalo Bills visit the Los Angeles Rams in Week 5 of the 2026 NFL season, on Monday, October 12 at 8:15 PM ET at SoFi Stadium. Dome · Matrixturf. The Bills are 2-0 (1st in the AFC East), the Rams 1-1 (3rd in the NFC West). The Bills went 5-1 down the stretch, the Rams 4-2.
In 2026 the Bills scored 38.5 points per game (1st in the NFL) and allowed 31 (28th in the NFL); the Rams scored 17.5 (22nd in the NFL) and allowed 16.5 (8th in the NFL).
Head-to-head, the recent series reads BUF 2–1 over the last 3 meetings, at an average total of 64.7; against the spread it is BUF 2–1, and the total has gone OVER 2–1. BUF have taken 2 of the last 3 — 2 of the 3 landed inside a score.
Injury report: 11 players out and 18 questionable across the two teams — Jordan Hancock (BUF CB, Injured reserve), Kamren Kinchens (LAR S, Doubtful), T.J. Sanders (BUF DT, Out) and Puka Nacua (LAR WR, Doubtful).
Frequently asked questions
When do the Bills play the Rams?
Buffalo Bills at Los Angeles Rams is Week 5 of the 2026 NFL season, kicking off on Monday, October 12 at 8:15 PM ET at SoFi Stadium.
What is the head-to-head record between the Bills and the Rams?
The recent series is BUF 2–1 over the last 3 meetings — the last one finished LAR 44–42 in 2024 (Week 14), and against the spread the series is BUF 2–1.
Who is injured for Bills vs Rams?
53 players carry a designation: 11 out and 18 questionable, including Jordan Hancock (BUF CB, Injured reserve), Kamren Kinchens (LAR S, Doubtful), T.J. Sanders (BUF DT, Out) and Puka Nacua (LAR WR, Doubtful). The report refreshes with the data sync before game days and the model prices designations in automatically.