The Buffalo Bills visit the Denver Broncos in Week 16 of the 2026 NFL season, on Friday, December 25 at 4:30 PM ET at Empower Field at Mile High. Open air · Grass. The Bills are 7-1 (1st in the AFC East), the Broncos 7-2 (1st in the AFC West). The Bills went 5-1 down the stretch, the Broncos 5-1.
In 2026 the Bills scored 32 points per game (1st in the NFL) and allowed 23.4 (16th in the NFL); the Broncos scored 22 (20th in the NFL) and allowed 20.7 (10th in the NFL).
Head-to-head, the recent series reads BUF 3–2 over the last 5 meetings, at an average total of 47.4; against the spread it is BUF 3–2, and the total has gone UNDER 3–2. BUF have taken 3 of the last 5 — 2 of the 5 landed inside a score.
Injury report: 12 players out and 16 questionable across the two teams — Joshua Palmer (BUF WR, Injured reserve), Tyrell Shavers (BUF WR, Reserve/PUP), Talanoa Hufanga (DEN S, Out) and Brandon Jones (DEN S, Out).
| Buffalo Bills | Denver Broncos | |
|---|---|---|
| Record | 7-1 | 7-2 |
| Division | 1st AFC E | 1st AFC W |
| Last six results | W L W W W W | L W W W W W |
| Points / G | 32 (1st) | 22 (20th) |
| Total Yds / G | 400 (1st) | 283.7 (31st) |
| Yards / Play | 6.2 (4th) | 4.9 (30th) |
| Pass Yds / G | 253.4 (12th) | 192.2 (28th) |
| Rush Yds / G | 146.6 (2nd) | 91.4 (27th) |
| 3rd Down % | 43.2% (8th) | 32.4% (31st) |
| 1st Downs / G | 23.6 (1st) | 18.2 (22nd) |
| Turnover Diff | 0 (16th) | +5 (7th) |
| Pts Allowed / G | 23.4 (16th) | 20.7 (10th) |
| Yds Allowed / G | 344.4 (15th) | 374.2 (25th) |
| Pass Yds Allowed | 252.8 (27th) | 249.9 (25th) |
| Rush Yds Allowed | 91.6 (7th) | 124.3 (23rd) |
| Sacks | 17 (19th) | 26 (8th) |
| Player | Team | Position | Status | Injury |
|---|---|---|---|---|
| Joshua Palmer | BUF | WR | Injured reserve | Hamstring |
| Greg Gaines | BUF | DT | Questionable | Calf |
| Alec Anderson | BUF | OT | Questionable | Ankle |
| Dion Dawkins | BUF | OT | Questionable | Rib |
| Tyrell Shavers | BUF | WR | Reserve/PUP | Knee |
| Talanoa Hufanga | DEN | S | Out | Ankle |
| Brandon Jones | DEN | S | Out | Hamstring |
| Kris Abrams-Draine | DEN | CB | Out | Ankle |
| Jaylen Waddle | DEN | WR | Questionable | Chest |
| Riley Moss | DEN | CB | Questionable | Ribs |
| Eyioma Uwazurike | DEN | DE | Injured reserve | Shoulder |
| Jordan Hancock | BUF | CB | IR, designated to return | Hamstring |
| RJ Harvey | DEN | RB | Injured reserve | Knee |
| Tyler Badie | DEN | RB | Injured reserve | Thumb |
| Jonah Elliss | DEN | LB | Injured reserve | Ankle |
| Dorian Strong | BUF | CB | Reserve/NFI | |
| Zane Durant | BUF | DT | IR, designated to return | |
| Nick Gargiulo | DEN | G | Reserve/PUP | Knee |
| Frank Crum | DEN | OT | IR, designated to return | Undisclosed |
| Caleb Lohner | DEN | TE | IR, designated to return | Lower body |
| Levelle Bailey | DEN | LB | Injured reserve | Leg |
| Michael Deiter | DEN | C | Injured reserve | |
| Matt Henningsen | DEN | DE | Injured reserve | |
| Jordan Phillips | BUF | DT | Injured Reserve | |
| Jordan Poyer | BUF | S | Questionable | |
| Taylor Rapp | BUF | S | Injured Reserve | |
| Chase Lundt | BUF | OT | Questionable | |
| Ed Oliver | BUF | DT | Questionable | |
| Terrel Bernard | BUF | LB | Questionable | |
| Michael Hoecht | BUF | DE | Injured Reserve | |
| DeWayne Carter | BUF | DT | Injured Reserve | |
| Dorian Williams | BUF | LB | Questionable | |
| Demetrius Flannigan-Fowles | BUF | LB | Injured Reserve | |
| Keon Coleman | BUF | WR | Questionable | |
| Te'Cory Couch | BUF | CB | Questionable | |
| Michael Burton | DEN | FB | Injured Reserve | |
| Matt Peart | DEN | OT | Injured Reserve | |
| Delarrin Turner-Yell | DEN | S | Questionable | |
| Drew Sanders | DEN | LB | Injured Reserve | |
| Reese Taylor | DEN | CB | Questionable | |
| Gavin Ortega | DEN | OT | Out | |
| Marvin Mims Jr. | DEN | WR | Questionable | |
| Sai'vion Jones | DEN | DE | Questionable |
BUF have taken 3 of the last 5 — 2 of the 5 landed inside a score.
| Game | Winner | Score | Venue |
|---|---|---|---|
| 2025 DIV | DEN | 33–30 | Empower Field at Mile High |
| 2024 WC | BUF | 31–7 | Highmark Stadium |
| 2023 Week 10 | DEN | 24–22 | Highmark Stadium |
| 2020 Week 15 | BUF | 48–19 | Empower Field at Mile High |
| 2019 Week 12 | BUF | 20–3 | Highmark Stadium |