The Buffalo Bills visit the Denver Broncos in Week 16 of the 2026 NFL season, on Friday, December 25 at 4:30 PM ET at Empower Field at Mile High. Open air · Grass. The Bills are 2-0 (1st in the AFC East), the Broncos 1-1 (3rd in the AFC West). The Bills went 5-1 down the stretch, the Broncos 4-2.
In 2026 the Bills scored 38.5 points per game (1st in the NFL) and allowed 31 (28th in the NFL); the Broncos scored 15 (29th in the NFL) and allowed 22 (13th in the NFL).
Head-to-head, the recent series reads BUF 3–2 over the last 5 meetings, at an average total of 47.4; against the spread it is BUF 3–2, and the total has gone UNDER 3–2. BUF have taken 3 of the last 5 — 2 of the 5 landed inside a score.
Injury report: 10 players out and 15 questionable across the two teams — Jonah Coleman (DEN RB, Injured reserve), Jordan Hancock (BUF CB, Injured reserve), T.J. Sanders (BUF DT, Out) and Tyrell Shavers (BUF WR, Reserve/PUP).
Frequently asked questions
When do the Bills play the Broncos?
Buffalo Bills at Denver Broncos is Week 16 of the 2026 NFL season, kicking off on Friday, December 25 at 4:30 PM ET at Empower Field at Mile High.
What is the head-to-head record between the Bills and the Broncos?
The recent series is BUF 3–2 over the last 5 meetings — the last one finished DEN 33–30 in 2025 (DIV), and against the spread the series is BUF 3–2.
Who is injured for Bills vs Broncos?
47 players carry a designation: 10 out and 15 questionable, including Jonah Coleman (DEN RB, Injured reserve), Jordan Hancock (BUF CB, Injured reserve), T.J. Sanders (BUF DT, Out) and Tyrell Shavers (BUF WR, Reserve/PUP). The report refreshes with the data sync before game days and the model prices designations in automatically.