The Kansas City Chiefs visit the Buffalo Bills in Week 12 of the 2026 NFL season, on Thursday, November 26 at 8:20 PM ET at Highmark Stadium. Open air · A_turf. The Chiefs are 6-2 (2nd in the AFC West), the Bills 7-1 (1st in the AFC East). The Chiefs went 4-2 down the stretch, the Bills 5-1.
In 2026 the Chiefs scored 25.3 points per game (10th in the NFL) and allowed 17.9 (3rd in the NFL); the Bills scored 32 (1st in the NFL) and allowed 23.4 (16th in the NFL).
Head-to-head, the recent series reads BUF 4–2 over the last 6 meetings, at an average total of 48.8; against the spread it is BUF 4–2, and the total has gone OVER 3–3. BUF have taken 4 of the last 6 — 5 of the 6 landed inside a score.
Injury report: 15 players out and 19 questionable across the two teams — Joshua Palmer (BUF WR, Injured reserve), Tyrell Shavers (BUF WR, Reserve/PUP), Jordan Hancock (BUF CB, IR, designated to return) and L'Jarius Sneed (KC CB, Injured reserve).
| Kansas City Chiefs | Buffalo Bills | |
|---|---|---|
| Record | 6-2 | 7-1 |
| Division | 2nd AFC W | 1st AFC E |
| Last six results | W W W L L W | W L W W W W |
| Points / G | 25.3 (10th) | 32 (1st) |
| Total Yds / G | 392.4 (4th) | 400 (1st) |
| Yards / Play | 6.4 (2nd) | 6.2 (4th) |
| Pass Yds / G | 254.6 (11th) | 253.4 (12th) |
| Rush Yds / G | 137.8 (5th) | 146.6 (2nd) |
| 3rd Down % | 41.7% (9th) | 43.2% (8th) |
| 1st Downs / G | 20.8 (9th) | 23.6 (1st) |
| Turnover Diff | +4 (9th) | 0 (16th) |
| Pts Allowed / G | 17.9 (3rd) | 23.4 (16th) |
| Yds Allowed / G | 318 (7th) | 344.4 (15th) |
| Pass Yds Allowed | 220.5 (7th) | 252.8 (27th) |
| Rush Yds Allowed | 97.5 (10th) | 91.6 (7th) |
| Sacks | 14 (29th) | 17 (19th) |
| Player | Team | Position | Status | Injury |
|---|---|---|---|---|
| Mansoor Delane | KC | CB | Questionable | Shoulder |
| Peter Woods | KC | DT | Questionable | Neck |
| Joshua Palmer | BUF | WR | Injured reserve | Hamstring |
| Jaylon Moore | KC | OT | Questionable | Concussion |
| Greg Gaines | BUF | DT | Questionable | Calf |
| Alec Anderson | BUF | OT | Questionable | Ankle |
| Dion Dawkins | BUF | OT | Questionable | Rib |
| Tyrell Shavers | BUF | WR | Reserve/PUP | Knee |
| Xavier Worthy | KC | WR | Questionable | Shoulder |
| Patrick Mahomes | KC | QB | Questionable | Knee |
| Jordan Hancock | BUF | CB | IR, designated to return | Hamstring |
| L'Jarius Sneed | KC | CB | Injured reserve | Knee |
| Omarr Norman-Lott | KC | DT | Reserve/PUP | Knee |
| Brashard Smith | KC | RB | Injured reserve | Hamstring |
| Josh Simmons | KC | OT | Injured reserve | Back |
| Tyquan Thornton | KC | WR | Injured reserve | Ankle |
| Dorian Strong | BUF | CB | Reserve/NFI | |
| Zane Durant | BUF | DT | IR, designated to return | |
| Jimmy Holiday | KC | WR | Injured reserve | Undisclosed |
| Jeff Caldwell | KC | WR | Injured reserve | Knee |
| Matt Waletzko | KC | OT | Injured reserve | Undisclosed |
| Ethan Downs | KC | LB | Injured reserve | Downs |
| John Michael Gyllenborg | KC | TE | Injured reserve | |
| Keaontay Ingram | KC | RB | Injured Reserve | |
| Trent McDuffie | KC | CB | Injured Reserve | |
| Janarius Robinson | KC | DE | Injured Reserve | |
| Brandon George | KC | LB | Questionable | |
| Kader Kohou | KC | CB | Questionable | |
| Leo Chenal | KC | LB | Injured Reserve | |
| Deon Bush | KC | S | Injured Reserve | |
| C.J. Hanson | KC | G | Injured Reserve | |
| Chukwuebuka Godrick | KC | OT | Questionable | |
| Chris Oladokun | KC | QB | Injured Reserve | |
| Ethan Driskell | KC | OT | Out | |
| Cooper McDonald | KC | LB | Injured Reserve | |
| Tyreke Smith | KC | DE | Out | |
| EJ Smith | KC | RB | Questionable | |
| Jordan Phillips | BUF | DT | Injured Reserve | |
| Jordan Poyer | BUF | S | Questionable | |
| Taylor Rapp | BUF | S | Injured Reserve | |
| Chase Lundt | BUF | OT | Questionable | |
| Ed Oliver | BUF | DT | Questionable | |
| Terrel Bernard | BUF | LB | Questionable | |
| Michael Hoecht | BUF | DE | Injured Reserve | |
| DeWayne Carter | BUF | DT | Injured Reserve | |
| Dorian Williams | BUF | LB | Questionable | |
| Demetrius Flannigan-Fowles | BUF | LB | Injured Reserve | |
| Keon Coleman | BUF | WR | Questionable | |
| Te'Cory Couch | BUF | CB | Questionable |
BUF have taken 4 of the last 6 — 5 of the 6 landed inside a score.
| Game | Winner | Score | Venue |
|---|---|---|---|
| 2025 Week 9 | BUF | 28–21 | Highmark Stadium |
| 2024 CONF | KC | 32–29 | GEHA Field at Arrowhead Stadium |
| 2024 Week 11 | BUF | 30–21 | Highmark Stadium |
| 2023 DIV | KC | 27–24 | Highmark Stadium |
| 2023 Week 14 | BUF | 20–17 | GEHA Field at Arrowhead Stadium |
| 2022 Week 6 | BUF | 24–20 | GEHA Field at Arrowhead Stadium |