The Kansas City Chiefs visit the Buffalo Bills in Week 12 of the 2026 NFL season, on Thursday, November 26 at 8:20 PM ET at Highmark Stadium. Open air · A_turf. The Chiefs are 2-0 (2nd in the AFC West), the Bills 2-0 (1st in the AFC East). The Chiefs went 3-3 down the stretch, the Bills 5-1.
In 2026 the Chiefs scored 32 points per game (3rd in the NFL) and allowed 20 (11th in the NFL); the Bills scored 38.5 (1st in the NFL) and allowed 31 (28th in the NFL).
Head-to-head, the recent series reads BUF 4–2 over the last 6 meetings, at an average total of 48.8; against the spread it is BUF 4–2, and the total has gone OVER 3–3. BUF have taken 4 of the last 6 — 5 of the 6 landed inside a score.
Injury report: 14 players out and 21 questionable across the two teams — Jordan Hancock (BUF CB, Injured reserve), T.J. Sanders (BUF DT, Out), Cooper McDonald (KC LB, Injured reserve) and Tyrell Shavers (BUF WR, Reserve/PUP).
Frequently asked questions
When do the Chiefs play the Bills?
Kansas City Chiefs at Buffalo Bills is Week 12 of the 2026 NFL season, kicking off on Thursday, November 26 at 8:20 PM ET at Highmark Stadium.
What is the head-to-head record between the Chiefs and the Bills?
The recent series is BUF 4–2 over the last 6 meetings — the last one finished BUF 28–21 in 2025 (Week 9), and against the spread the series is BUF 4–2.
Who is injured for Chiefs vs Bills?
56 players carry a designation: 14 out and 21 questionable, including Jordan Hancock (BUF CB, Injured reserve), T.J. Sanders (BUF DT, Out), Cooper McDonald (KC LB, Injured reserve) and Tyrell Shavers (BUF WR, Reserve/PUP). The report refreshes with the data sync before game days and the model prices designations in automatically.