The New England Patriots visit the Buffalo Bills in Week 4 of the 2026 NFL season, on Sunday, October 4 at 1:00 PM ET at Highmark Stadium. Open air · A_turf. The Patriots are 1-2 (3rd in the AFC East), the Bills 3-0 (1st in the AFC East). The Patriots went 3-3 down the stretch, the Bills 5-1.
In 2026 the Patriots scored 15 points per game (27th in the NFL) and allowed 8 (1st in the NFL); the Bills scored 38.5 (1st in the NFL) and allowed 31 (28th in the NFL).
Head-to-head, the recent series reads BUF 3–3 over the last 6 meetings, at an average total of 49.2; against the spread it is NE 5–1, and the total has gone OVER 4–2. The last 6 meetings are split 3–3 — 6 of the 6 landed inside a score.
Injury report: 12 players out and 18 questionable across the two teams — Quintayvious Hutchins (NE LB, Injured reserve), Jordan Hancock (BUF CB, Injured reserve), Dell Pettus (NE S, Injured reserve) and Brenden Schooler (NE S, Reserve/NFI).
Frequently asked questions
When do the Patriots play the Bills?
New England Patriots at Buffalo Bills is Week 4 of the 2026 NFL season, kicking off on Sunday, October 4 at 1:00 PM ET at Highmark Stadium.
What is the head-to-head record between the Patriots and the Bills?
The recent series is BUF 3–3 over the last 6 meetings — the last one finished BUF 35–31 in 2025 (Week 15), and against the spread the series is NE 5–1.
Who is injured for Patriots vs Bills?
64 players carry a designation: 12 out and 18 questionable, including Quintayvious Hutchins (NE LB, Injured reserve), Jordan Hancock (BUF CB, Injured reserve), Dell Pettus (NE S, Injured reserve) and Brenden Schooler (NE S, Reserve/NFI). The report refreshes with the data sync before game days and the model prices designations in automatically.