Buffalo Bills vs New England Patriots Prediction, Odds & Props — Week 13

The Buffalo Bills visit the New England Patriots in Week 13 of the 2026 NFL season, on Sunday, December 6 at 4:25 PM ET at Gillette Stadium. Open air · Fieldturf. The Bills are 7-1 (1st in the AFC East), the Patriots 5-4 (2nd in the AFC East). The Bills went 5-1 down the stretch, the Patriots 4-2.

In 2026 the Bills scored 32 points per game (1st in the NFL) and allowed 23.4 (16th in the NFL); the Patriots scored 23.4 (14th in the NFL) and allowed 23 (15th in the NFL).

Head-to-head, the recent series reads NE 3–3 over the last 6 meetings, at an average total of 49.3; against the spread it is NE 5–1, and the total has gone OVER 4–2. The last 6 meetings are split 3–3 — 6 of the 6 landed inside a score.

Injury report: 15 players out and 18 questionable across the two teams — Rhamondre Stevenson (NE RB, Doubtful), Joshua Palmer (BUF WR, Injured reserve), Ben Brown (NE C, Doubtful) and Tyrell Shavers (BUF WR, Reserve/PUP).

All Bills v Patriots games

• Buffalo Bills stats, schedule and roster
• New England Patriots stats, schedule and roster

The last 6 meetings are split 3–3 — 6 of the 6 landed inside a score.