Myles Garrett led the NFL in sacks in the 2025 regular season with 23.
Next came Brian Burns (16.5) and Danielle Hunter (15) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Sacks |
|---|---|---|---|---|
| 1 | Myles Garrett | CLE | DE | 23 |
| 2 | Brian Burns | NYG | LB | 16.5 |
| 3 | Danielle Hunter | HOU | DE | 15 |
| 4 | Aidan Hutchinson | DET | DE | 14.5 |
| 5 | Nik Bonitto | DEN | LB | 14 |
| 6 | Tuli Tuipulotu | LAC | LB | 13 |
| 7 | Micah Parsons | GB | DE | 12.5 |
| 8 | Will Anderson Jr. | HOU | DE | 12 |
| 9 | Byron Young | LAR | LB | 12 |
| 10 | Josh Sweat | ARI | LB | 12 |
| 11 | Jeffery Simmons | TEN | DT | 11 |
| 12 | Al-Quadin Muhammad | TB | LB | 11 |
| 13 | Cameron Jordan | NO | DE | 10.5 |
| 14 | James Pearce Jr. | ATL | LB | 10.5 |
| 15 | Maxx Crosby | LV | DE | 10 |
| 16 | Montez Sweat | CHI | DE | 10 |
| 17 | Chase Young | NO | DE | 10 |
| 18 | Alex Highsmith | PIT | LB | 9.5 |
| 19 | Von Miller | WSH | LB | 9 |
| 20 | Harold Landry III | NE | LB | 8.5 |
| 21 | Bradley Chubb | BUF | LB | 8.5 |
| 22 | Laiatu Latu | IND | DE | 8.5 |
| 23 | Brandon Dorlus | ATL | DT | 8.5 |
| 24 | Jadeveon Clowney | DAL | DE | 8.5 |
| 25 | Will McDonald IV | NYJ | DE | 8 |