Trey Hendrickson led the NFL in sacks in the 2024 regular season with 17.5.
Next came Myles Garrett (14) and Nik Bonitto (13.5) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Sacks |
|---|---|---|---|---|
| 1 | Trey Hendrickson | BAL | LB | 17.5 |
| 2 | Myles Garrett | CLE | DE | 14 |
| 3 | Nik Bonitto | DEN | LB | 13.5 |
| 4 | Kyle Van Noy | BAL | LB | 12.5 |
| 5 | Danielle Hunter | HOU | DE | 12 |
| 6 | Jonathan Greenard | PHI | LB | 12 |
| 7 | Micah Parsons | GB | DE | 12 |
| 8 | T.J. Watt | PIT | LB | 11.5 |
| 9 | Andrew Van Ginkel | MIN | LB | 11.5 |
| 10 | Leonard Williams | SEA | DT | 11 |
| 11 | Will Anderson Jr. | HOU | DE | 11 |
| 12 | Will McDonald IV | NYJ | DE | 10.5 |
| 13 | Jonathon Cooper | DEN | LB | 10.5 |
| 14 | Travon Walker | JAX | DE | 10.5 |
| 15 | Dante Fowler Jr. | DAL | LB | 10.5 |
| 16 | Odafe Oweh | WSH | LB | 10 |
| 17 | Zach Sieler | MIA | DT | 10 |
| 18 | Harold Landry III | NE | LB | 9 |
| 19 | Nick Bosa | SF | DE | 9 |
| 20 | Za'Darius Smith | PHI | DE | 9 |
| 21 | Dexter Lawrence II | CIN | DT | 9 |
| 22 | Leonard Floyd | ATL | DE | 8.5 |
| 23 | Zach Allen | DEN | DE | 8.5 |
| 24 | Brian Burns | NYG | LB | 8.5 |
| 25 | Braden Fiske | LAR | DE | 8.5 |