Shaquil Barrett led the NFL in sacks in the 2019 regular season with 19.5.
Next came Chandler Jones (19) and Cameron Jordan (15.5) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Sacks |
|---|---|---|---|---|
| 1 | Shaquil Barrett | TB | UNK | 19.5 |
| 2 | Chandler Jones | LV | UNK | 19 |
| 3 | Cameron Jordan | NO | DE | 15.5 |
| 4 | Danielle Hunter | HOU | DE | 14.5 |
| 5 | T.J. Watt | PIT | LB | 14.5 |
| 6 | Za'Darius Smith | PHI | DE | 13.5 |
| 7 | Aaron Donald | LAR | DT | 12.5 |
| 8 | Preston Smith | WSH | LB | 12 |
| 9 | Robert Quinn | PHI | UNK | 11.5 |
| 10 | Bud Dupree | LAC | LB | 11.5 |
| 11 | Dante Fowler Jr. | DAL | LB | 11.5 |
| 12 | Joey Bosa | BUF | DE | 11.5 |
| 13 | Justin Houston | BAL | UNK | 11 |
| 14 | Josh Hines-Allen | JAX | DE | 10.5 |
| 15 | Arik Armstead | JAX | DT | 10 |
| 16 | Markus Golden | ARI | UNK | 10 |
| 17 | Myles Garrett | CLE | DE | 10 |
| 18 | Maxx Crosby | LV | DE | 10 |
| 19 | Mario Addison | HOU | UNK | 9.5 |
| 20 | Jordan Phillips | BUF | DT | 9.5 |
| 21 | Matthew Judon | BUF | DE | 9.5 |
| 22 | Carlos Dunlap | KC | UNK | 9 |
| 23 | Cameron Heyward | PIT | DT | 9 |
| 24 | Chris Jones | KC | DT | 9 |
| 25 | Harold Landry III | NE | LB | 9 |