T.J. Watt led the NFL in sacks in the 2020 regular season with 15.
Next came Aaron Donald (13.5) and Trey Hendrickson (13.5) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Sacks |
|---|---|---|---|---|
| 1 | T.J. Watt | PIT | LB | 15 |
| 2 | Aaron Donald | LAR | DT | 13.5 |
| 3 | Trey Hendrickson | BAL | LB | 13.5 |
| 4 | Haason Reddick | TB | LB | 12.5 |
| 5 | Za'Darius Smith | PHI | DE | 12.5 |
| 6 | Myles Garrett | CLE | DE | 12 |
| 7 | Leonard Williams | SEA | DT | 11.5 |
| 8 | Stephon Tuitt | PIT | UNK | 11 |
| 9 | Leonard Floyd | ATL | DE | 10.5 |
| 10 | Romeo Okwara | DET | UNK | 10 |
| 11 | Jason Pierre-Paul | TB | LB | 9.5 |
| 12 | DeForest Buckner | IND | DT | 9.5 |
| 13 | Jamal Adams | LV | LB | 9.5 |
| 14 | Olivier Vernon | NYG | UNK | 9 |
| 15 | Khalil Mack | LAC | LB | 9 |
| 16 | Emmanuel Ogbah | JAX | DE | 9 |
| 17 | Montez Sweat | CHI | DE | 9 |
| 18 | Devin White | LV | LB | 9 |
| 19 | Brian Burns | NYG | LB | 9 |
| 20 | Kerry Hyder Jr. | SF | UNK | 8.5 |
| 21 | Brandon Graham | PHI | DE | 8 |
| 22 | Justin Houston | BAL | UNK | 8 |
| 23 | Shaquil Barrett | TB | UNK | 8 |
| 24 | Bud Dupree | LAC | LB | 8 |
| 25 | Yannick Ngakoue | BAL | UNK | 8 |