Nick Bosa led the NFL in sacks in the 2022 regular season with 18.5.
Next came Haason Reddick (16) and Myles Garrett (16) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Sacks |
|---|---|---|---|---|
| 1 | Nick Bosa | SF | DE | 18.5 |
| 2 | Haason Reddick | TB | LB | 16 |
| 3 | Myles Garrett | CLE | DE | 16 |
| 4 | Chris Jones | KC | DT | 15.5 |
| 5 | Matthew Judon | BUF | DE | 15.5 |
| 6 | Alex Highsmith | PIT | LB | 14.5 |
| 7 | Micah Parsons | GB | DE | 13.5 |
| 8 | J.J. Watt | ARI | UNK | 12.5 |
| 9 | Maxx Crosby | LV | DE | 12.5 |
| 10 | Brian Burns | NYG | LB | 12.5 |
| 11 | Quinnen Williams | DAL | DT | 12 |
| 12 | Daron Payne | WSH | DT | 11.5 |
| 13 | Josh Uche | MIA | LB | 11.5 |
| 14 | Brandon Graham | PHI | DE | 11 |
| 15 | Javon Hargrave | GB | DT | 11 |
| 16 | Josh Sweat | ARI | LB | 11 |
| 17 | Cameron Heyward | PIT | DT | 10.5 |
| 18 | Danielle Hunter | HOU | DE | 10.5 |
| 19 | Za'Darius Smith | PHI | DE | 10 |
| 20 | Justin Houston | BAL | UNK | 9.5 |
| 21 | Yannick Ngakoue | BAL | UNK | 9.5 |
| 22 | Uchenna Nwosu | SEA | LB | 9.5 |
| 23 | Darrell Taylor | NE | DE | 9.5 |
| 24 | Aidan Hutchinson | DET | DE | 9.5 |
| 25 | Jerry Hughes | HOU | UNK | 9 |