Aaron Donald led the NFL in sacks in the 2018 regular season with 20.5.
Next came J.J. Watt (16) and Chris Jones (15.5) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Sacks |
|---|---|---|---|---|
| 1 | Aaron Donald | LAR | DT | 20.5 |
| 2 | J.J. Watt | ARI | UNK | 16 |
| 3 | Chris Jones | KC | DT | 15.5 |
| 4 | Von Miller | WSH | LB | 14.5 |
| 5 | Danielle Hunter | HOU | DE | 14.5 |
| 6 | Frank Clark | SEA | UNK | 14 |
| 7 | Myles Garrett | CLE | DE | 13.5 |
| 8 | Ryan Kerrigan | PHI | UNK | 13 |
| 9 | Chandler Jones | LV | UNK | 13 |
| 10 | Dee Ford | SF | UNK | 13 |
| 11 | T.J. Watt | PIT | LB | 13 |
| 12 | Jason Pierre-Paul | TB | LB | 12.5 |
| 13 | Khalil Mack | LAC | LB | 12.5 |
| 14 | Cameron Jordan | NO | DE | 12 |
| 15 | DeForest Buckner | IND | DT | 12 |
| 16 | Bradley Chubb | BUF | LB | 12 |
| 17 | Calais Campbell | ARI | DE | 10.5 |
| 18 | Fletcher Cox | PHI | UNK | 10.5 |
| 19 | DeMarcus Lawrence | SEA | LB | 10.5 |
| 20 | Kyler Fackrell | LAC | UNK | 10.5 |
| 21 | Jarran Reed | SEA | DT | 10.5 |
| 22 | Geno Atkins | CIN | UNK | 10 |
| 23 | Yannick Ngakoue | BAL | UNK | 9.5 |
| 24 | Michael Bennett | PHI | UNK | 9 |
| 25 | Justin Houston | BAL | UNK | 9 |