T.J. Watt led the NFL in sacks in the 2021 regular season with 22.5.
Next came Robert Quinn (18.5) and Myles Garrett (16) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Sacks |
|---|---|---|---|---|
| 1 | T.J. Watt | PIT | LB | 22.5 |
| 2 | Robert Quinn | PHI | UNK | 18.5 |
| 3 | Myles Garrett | CLE | DE | 16 |
| 4 | Nick Bosa | SF | DE | 15.5 |
| 5 | Trey Hendrickson | BAL | LB | 14 |
| 6 | Micah Parsons | GB | DE | 13 |
| 7 | Cameron Jordan | NO | DE | 12.5 |
| 8 | Aaron Donald | LAR | DT | 12.5 |
| 9 | Matthew Judon | BUF | DE | 12.5 |
| 10 | Harold Landry III | NE | LB | 12 |
| 11 | Markus Golden | ARI | UNK | 11 |
| 12 | Haason Reddick | TB | LB | 11 |
| 13 | Chandler Jones | LV | UNK | 10.5 |
| 14 | Joey Bosa | BUF | DE | 10.5 |
| 15 | Cameron Heyward | PIT | DT | 10 |
| 16 | Shaquil Barrett | TB | UNK | 10 |
| 17 | Yannick Ngakoue | BAL | UNK | 10 |
| 18 | Von Miller | WSH | LB | 9.5 |
| 19 | Leonard Floyd | ATL | DE | 9.5 |
| 20 | Rashan Gary | DAL | LB | 9.5 |
| 21 | Jadeveon Clowney | DAL | DE | 9 |
| 22 | Denico Autry | HOU | DE | 9 |
| 23 | Preston Smith | WSH | LB | 9 |
| 24 | Emmanuel Ogbah | JAX | DE | 9 |
| 25 | Chris Jones | KC | DT | 9 |