James Cook III led the NFL in rushing yards in the 2025 regular season with 1,621.
Next came Derrick Henry (1,595) and Jonathan Taylor (1,585) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Rushing Yards |
|---|---|---|---|---|
| 1 | James Cook III | BUF | RB | 1,621 |
| 2 | Derrick Henry | BAL | RB | 1,595 |
| 3 | Jonathan Taylor | IND | RB | 1,585 |
| 4 | Bijan Robinson | ATL | RB | 1,478 |
| 5 | De'Von Achane | MIA | RB | 1,350 |
| 6 | Kyren Williams | LAR | RB | 1,252 |
| 7 | Jahmyr Gibbs | DET | RB | 1,223 |
| 8 | Christian McCaffrey | SF | RB | 1,202 |
| 9 | Javonte Williams | DAL | RB | 1,201 |
| 10 | Saquon Barkley | PHI | RB | 1,140 |
| 11 | Travis Etienne Jr. | NO | RB | 1,107 |
| 12 | D'Andre Swift | CHI | RB | 1,087 |
| 13 | Tony Pollard | TEN | RB | 1,082 |
| 14 | Rico Dowdle | PIT | RB | 1,076 |
| 15 | Breece Hall | NYJ | RB | 1,065 |
| 16 | Kenneth Walker III | KC | RB | 1,027 |
| 17 | Chase Brown | CIN | RB | 1,019 |
| 18 | Ashton Jeanty | LV | RB | 975 |
| 19 | Jaylen Warren | PIT | RB | 958 |
| 20 | Josh Jacobs | GB | RB | 929 |
| 21 | TreVeyon Henderson | NE | RB | 911 |
| 22 | Quinshon Judkins | CLE | RB | 827 |
| 23 | Jacory Croskey-Merritt | WSH | RB | 805 |
| 24 | Kyle Monangai | CHI | RB | 783 |
| 25 | J.K. Dobbins | DEN | RB | 772 |