Jonathan Taylor led the NFL in rushing yards in the 2021 regular season with 1,811.
Next came Nick Chubb (1,259) and Joe Mixon (1,205) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Rushing Yards |
|---|---|---|---|---|
| 1 | Jonathan Taylor | IND | RB | 1,811 |
| 2 | Nick Chubb | HOU | RB | 1,259 |
| 3 | Joe Mixon | CIN | RB | 1,205 |
| 4 | Najee Harris | LAC | RB | 1,200 |
| 5 | Dalvin Cook | DAL | UNK | 1,159 |
| 6 | Antonio Gibson | NE | RB | 1,037 |
| 7 | Ezekiel Elliott | DAL | UNK | 1,002 |
| 8 | Elijah Mitchell | NE | RB | 963 |
| 9 | Derrick Henry | BAL | RB | 937 |
| 10 | Damien Harris | BUF | RB | 929 |
| 11 | Melvin Gordon III | BAL | UNK | 918 |
| 12 | Austin Ekeler | WSH | RB | 911 |
| 13 | Javonte Williams | DAL | RB | 903 |
| 14 | Alvin Kamara | NO | RB | 898 |
| 15 | Josh Jacobs | GB | RB | 872 |
| 16 | Devin Singletary | NYG | RB | 870 |
| 17 | David Montgomery | HOU | RB | 849 |
| 18 | Sony Michel | LAC | UNK | 845 |
| 19 | AJ Dillon | CAR | RB | 803 |
| 20 | Aaron Jones Sr. | MIN | RB | 799 |
| 21 | Jalen Hurts | PHI | QB | 784 |
| 22 | Lamar Jackson | BAL | QB | 767 |
| 23 | Josh Allen | BUF | QB | 763 |
| 24 | Miles Sanders | DAL | RB | 754 |
| 25 | James Conner | ARI | RB | 752 |