Derrick Henry led the NFL in rushing yards in the 2020 regular season with 2,027.
Next came Dalvin Cook (1,557) and Jonathan Taylor (1,169) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Rushing Yards |
|---|---|---|---|---|
| 1 | Derrick Henry | BAL | RB | 2,027 |
| 2 | Dalvin Cook | DAL | UNK | 1,557 |
| 3 | Jonathan Taylor | IND | RB | 1,169 |
| 4 | Aaron Jones Sr. | MIN | RB | 1,104 |
| 5 | James Robinson | GB | UNK | 1,070 |
| 6 | David Montgomery | HOU | RB | 1,070 |
| 7 | Nick Chubb | HOU | RB | 1,067 |
| 8 | Josh Jacobs | GB | RB | 1,065 |
| 9 | Lamar Jackson | BAL | QB | 1,005 |
| 10 | Melvin Gordon III | BAL | UNK | 986 |
| 11 | Ezekiel Elliott | DAL | UNK | 979 |
| 12 | Ronald Jones | DAL | RB | 978 |
| 13 | Kenyan Drake | BAL | UNK | 955 |
| 14 | Alvin Kamara | NO | RB | 932 |
| 15 | Miles Sanders | DAL | RB | 867 |
| 16 | Kareem Hunt | KC | RB | 841 |
| 17 | Kyler Murray | MIN | QB | 819 |
| 18 | J.K. Dobbins | DEN | RB | 805 |
| 19 | Clyde Edwards-Helaire | KC | RB | 803 |
| 20 | Antonio Gibson | NE | RB | 795 |
| 21 | Gus Edwards | LAC | UNK | 723 |
| 22 | James Conner | ARI | RB | 721 |
| 23 | David Johnson | HOU | UNK | 691 |
| 24 | Damien Harris | BUF | RB | 691 |
| 25 | Devin Singletary | NYG | RB | 687 |