Josh Jacobs led the NFL in rushing yards in the 2022 regular season with 1,653.
Next came Derrick Henry (1,538) and Nick Chubb (1,525) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Rushing Yards |
|---|---|---|---|---|
| 1 | Josh Jacobs | GB | RB | 1,653 |
| 2 | Derrick Henry | BAL | RB | 1,538 |
| 3 | Nick Chubb | HOU | RB | 1,525 |
| 4 | Saquon Barkley | PHI | RB | 1,312 |
| 5 | Miles Sanders | DAL | RB | 1,269 |
| 6 | Dalvin Cook | DAL | UNK | 1,173 |
| 7 | Justin Fields | KC | QB | 1,143 |
| 8 | Christian McCaffrey | SF | RB | 1,139 |
| 9 | Travis Etienne Jr. | NO | RB | 1,125 |
| 10 | Aaron Jones Sr. | MIN | RB | 1,121 |
| 11 | Jamaal Williams | NO | UNK | 1,066 |
| 12 | Kenneth Walker III | KC | RB | 1,050 |
| 13 | Rhamondre Stevenson | NE | RB | 1,040 |
| 14 | Tyler Allgeier | ARI | RB | 1,035 |
| 15 | Najee Harris | LAC | RB | 1,034 |
| 16 | Tony Pollard | TEN | RB | 1,007 |
| 17 | Dameon Pierce | PHI | RB | 939 |
| 18 | Austin Ekeler | WSH | RB | 915 |
| 19 | D'Onta Foreman | CAR | UNK | 914 |
| 20 | Alvin Kamara | NO | RB | 897 |
| 21 | Raheem Mostert | LV | RB | 891 |
| 22 | Ezekiel Elliott | DAL | UNK | 876 |
| 23 | Jonathan Taylor | IND | RB | 861 |
| 24 | Jeff Wilson Jr. | MIA | RB | 860 |
| 25 | Isiah Pacheco | DET | RB | 830 |