Christian McCaffrey led the NFL in rushing yards in the 2023 regular season with 1,459.
Next came Derrick Henry (1,167) and Kyren Williams (1,144) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Rushing Yards |
|---|---|---|---|---|
| 1 | Christian McCaffrey | SF | RB | 1,459 |
| 2 | Derrick Henry | BAL | RB | 1,167 |
| 3 | Kyren Williams | LAR | RB | 1,144 |
| 4 | James Cook III | BUF | RB | 1,122 |
| 5 | D'Andre Swift | CHI | RB | 1,049 |
| 6 | James Conner | ARI | RB | 1,040 |
| 7 | Najee Harris | LAC | RB | 1,035 |
| 8 | Joe Mixon | CIN | RB | 1,034 |
| 9 | David Montgomery | HOU | RB | 1,015 |
| 10 | Raheem Mostert | LV | RB | 1,012 |
| 11 | Travis Etienne Jr. | NO | RB | 1,008 |
| 12 | Tony Pollard | TEN | RB | 1,005 |
| 13 | Breece Hall | NYJ | RB | 994 |
| 14 | Rachaad White | WSH | RB | 990 |
| 15 | Bijan Robinson | ATL | RB | 976 |
| 16 | Saquon Barkley | PHI | RB | 962 |
| 17 | Jahmyr Gibbs | DET | RB | 945 |
| 18 | Isiah Pacheco | DET | RB | 935 |
| 19 | Kenneth Walker III | KC | RB | 905 |
| 20 | Chuba Hubbard | CAR | RB | 902 |
| 21 | Devin Singletary | NYG | RB | 898 |
| 22 | Lamar Jackson | BAL | QB | 821 |
| 23 | Jerome Ford | WSH | RB | 813 |
| 24 | Gus Edwards | LAC | UNK | 810 |
| 25 | Josh Jacobs | GB | RB | 805 |