Derrick Henry led the NFL in rushing yards in the 2019 regular season with 1,540.
Next came Nick Chubb (1,494) and Christian McCaffrey (1,387) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Rushing Yards |
|---|---|---|---|---|
| 1 | Derrick Henry | BAL | RB | 1,540 |
| 2 | Nick Chubb | HOU | RB | 1,494 |
| 3 | Christian McCaffrey | SF | RB | 1,387 |
| 4 | Ezekiel Elliott | DAL | UNK | 1,357 |
| 5 | Chris Carson | SEA | UNK | 1,230 |
| 6 | Lamar Jackson | BAL | QB | 1,206 |
| 7 | Leonard Fournette | TB | UNK | 1,152 |
| 8 | Josh Jacobs | GB | RB | 1,150 |
| 9 | Joe Mixon | CIN | RB | 1,137 |
| 10 | Dalvin Cook | DAL | UNK | 1,135 |
| 11 | Marlon Mack | IND | UNK | 1,091 |
| 12 | Aaron Jones Sr. | MIN | RB | 1,084 |
| 13 | Carlos Hyde | JAX | UNK | 1,070 |
| 14 | Mark Ingram II | HOU | UNK | 1,018 |
| 15 | Phillip Lindsay | IND | UNK | 1,011 |
| 16 | Saquon Barkley | PHI | RB | 1,003 |
| 17 | Sony Michel | LAC | UNK | 912 |
| 18 | Adrian Peterson | WSH | UNK | 898 |
| 19 | David Montgomery | HOU | RB | 889 |
| 20 | Todd Gurley | LAR | UNK | 857 |
| 21 | Miles Sanders | DAL | RB | 818 |
| 22 | Kenyan Drake | BAL | UNK | 817 |
| 23 | Alvin Kamara | NO | RB | 797 |
| 24 | Le'Veon Bell | BAL | UNK | 789 |
| 25 | Devin Singletary | NYG | RB | 775 |