Devin Bush led the NFL in pick sixes in the 2025 regular season with 2.
Next came DaRon Bland (1) and Jalyx Hunt (1) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Pick Sixes |
|---|---|---|---|---|
| 1 | Devin Bush | CHI | LB | 2 |
| 2 | DaRon Bland | DAL | CB | 1 |
| 3 | Jalyx Hunt | PHI | LB | 1 |
| 4 | Alohi Gilman | KC | S | 1 |
| 5 | Marcus Jones | NE | CB | 1 |
| 6 | Kenny Moore II | IND | CB | 1 |
| 7 | Ja'Quan McMillian | DEN | CB | 1 |
| 8 | Jamel Dean | PIT | CB | 1 |
| 9 | Anthony Nelson | TB | LB | 1 |
| 10 | Mike Jackson | CAR | CB | 1 |
| 11 | Jessie Bates III | ATL | S | 1 |
| 12 | Cody Barton | TEN | LB | 1 |
| 13 | Justin Reid | NO | S | 1 |
| 14 | Geno Stone | BUF | S | 1 |
| 15 | Devin Lloyd | CAR | LB | 1 |
| 16 | Ernest Jones IV | SEA | LB | 1 |
| 17 | Tyson Campbell | CLE | CB | 1 |
| 18 | Christian Benford | BUF | CB | 1 |
| 19 | Cobie Durant | DAL | CB | 1 |
| 20 | Kyle Dugger | CIN | S | 1 |
| 21 | Derek Stingley Jr. | HOU | CB | 1 |
| 22 | Dee Winters | DAL | LB | 1 |
| 23 | Antonio Johnson | JAX | S | 1 |
| 24 | Chau Smith-Wade | CAR | CB | 1 |
| 25 | Isaiah Rodgers | MIN | CB | 1 |