Kyle Dugger and Kendall Fuller shared the NFL lead in pick sixes in 2022 with 2.
Next came Marcus Jones (1) and Josh Sweat (1) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Pick Sixes |
|---|---|---|---|---|
| 1 | Kyle Dugger | CIN | S | 2 |
| 2 | Kendall Fuller | MIA | UNK | 2 |
| 3 | Marcus Jones | NE | CB | 1 |
| 4 | Josh Sweat | ARI | LB | 1 |
| 5 | Frankie Luvu | WSH | LB | 1 |
| 6 | Lorenzo Carter | ATL | UNK | 1 |
| 7 | Isaiah Simmons | CAR | S | 1 |
| 8 | Willie Gay Jr. | MIA | LB | 1 |
| 9 | Zaven Collins | ARI | LB | 1 |
| 10 | Talanoa Hufanga | DEN | S | 1 |
| 11 | Matt Milano | BUF | LB | 1 |
| 12 | Jonathan Greenard | PHI | LB | 1 |
| 13 | Rayshawn Jenkins | CLE | S | 1 |
| 14 | Landon Collins | WSH | UNK | 1 |
| 15 | Mike Edwards | KC | S | 1 |
| 16 | Julian Blackmon | NO | S | 1 |
| 17 | Andre Cisco | NYJ | S | 1 |
| 18 | Cobie Durant | DAL | CB | 1 |
| 19 | Rodney McLeod Jr. | CLE | UNK | 1 |
| 20 | Duron Harmon | CLE | UNK | 1 |
| 21 | Bryce Callahan | LAC | UNK | 1 |
| 22 | James Bradberry IV | PHI | UNK | 1 |
| 23 | Andrew Adams | TEN | UNK | 1 |
| 24 | Jonathan Jones | PHI | CB | 1 |
| 25 | De'Vondre Campbell | SF | UNK | 1 |