Marcus Peters led the NFL in pick sixes in the 2019 regular season with 3.
Next came Erik Harris (2) and Stephon Gilmore (2) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Pick Sixes |
|---|---|---|---|---|
| 1 | Marcus Peters | BAL | UNK | 3 |
| 2 | Erik Harris | ATL | UNK | 2 |
| 3 | Stephon Gilmore | MIN | UNK | 2 |
| 4 | Yannick Ngakoue | BAL | UNK | 1 |
| 5 | Jamie Collins Sr. | NE | UNK | 1 |
| 6 | Jamal Adams | LV | LB | 1 |
| 7 | Shaquille Leonard | IND | UNK | 1 |
| 8 | Jadeveon Clowney | DAL | DE | 1 |
| 9 | Fred Warner | SF | LB | 1 |
| 10 | A.J. Klein | BUF | UNK | 1 |
| 11 | Nate Gerry | PHI | UNK | 1 |
| 12 | Bradley Roby | PHI | UNK | 1 |
| 13 | Sean Murphy-Bunting | ARI | CB | 1 |
| 14 | Richard Sherman | TB | UNK | 1 |
| 15 | Tashaun Gipson Sr. | SF | UNK | 1 |
| 16 | C.J. Mosley | NYJ | UNK | 1 |
| 17 | Ha Ha Clinton-Dix | GB | UNK | 1 |
| 18 | Malcolm Butler | TEN | UNK | 1 |
| 19 | Eric Rowe | PIT | UNK | 1 |
| 20 | Quandre Diggs | TEN | S | 1 |
| 21 | Anthony Harris | PHI | UNK | 1 |
| 22 | Deion Jones | TB | LB | 1 |
| 23 | Brian Poole | ATL | UNK | 1 |
| 24 | Vernon Hargreaves III | HOU | UNK | 1 |
| 25 | Jabrill Peppers | PIT | S | 1 |