Alec Ogletree and Eddie Jackson shared the NFL lead in pick sixes in 2018 with 2.
Next came Chris Jones (1) and Khalil Mack (1) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Pick Sixes |
|---|---|---|---|---|
| 1 | Alec Ogletree | NYG | UNK | 2 |
| 2 | Eddie Jackson | BAL | UNK | 2 |
| 3 | Chris Jones | KC | DT | 1 |
| 4 | Khalil Mack | LAC | LB | 1 |
| 5 | Jayon Brown | LV | UNK | 1 |
| 6 | Bud Dupree | LAC | LB | 1 |
| 7 | Vince Williams | PIT | UNK | 1 |
| 8 | Cory Littleton | HOU | UNK | 1 |
| 9 | Leonard Floyd | ATL | DE | 1 |
| 10 | Samson Ebukam | ATL | DE | 1 |
| 11 | Jerome Baker | CLE | LB | 1 |
| 12 | Myles Jack | PIT | UNK | 1 |
| 13 | Ron Parker | KC | UNK | 1 |
| 14 | Chris Harris Jr. | LAC | UNK | 1 |
| 15 | Bobby Wagner | WSH | LB | 1 |
| 16 | Shawn Williams | ATL | S | 1 |
| 17 | Antone Exum Jr. | SF | UNK | 1 |
| 18 | Telvin Smith | JAX | UNK | 1 |
| 19 | Malcolm Butler | TEN | UNK | 1 |
| 20 | Deion Jones | TB | LB | 1 |
| 21 | P.J. Williams | NO | UNK | 1 |
| 22 | Michael Johnson | CIN | UNK | 1 |
| 23 | Todd Davis | MIN | UNK | 1 |
| 24 | Johnathan Joseph | TEN | UNK | 1 |
| 25 | Devin McCourty | NE | UNK | 1 |