DaRon Bland led the NFL in pick sixes in the 2023 regular season with 5.
Next came Kenny Moore II (2) and Jack Jones (2) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Pick Sixes |
|---|---|---|---|---|
| 1 | DaRon Bland | DAL | CB | 5 |
| 2 | Kenny Moore II | IND | CB | 2 |
| 3 | Jack Jones | SF | CB | 2 |
| 4 | Brandin Echols | PIT | CB | 1 |
| 5 | Zach Sieler | MIA | DT | 1 |
| 6 | Jermaine Johnson II | TEN | DE | 1 |
| 7 | Alex Highsmith | PIT | LB | 1 |
| 8 | AJ Epenesa | BUF | DE | 1 |
| 9 | Andrew Van Ginkel | MIN | LB | 1 |
| 10 | Shaquil Barrett | TB | UNK | 1 |
| 11 | Jordyn Brooks | MIA | LB | 1 |
| 12 | Devon Witherspoon | SEA | CB | 1 |
| 13 | Kyle Hamilton | BAL | S | 1 |
| 14 | Foyesade Oluokun | JAX | LB | 1 |
| 15 | Quay Walker | LV | LB | 1 |
| 16 | Jason Pinnock | NYG | S | 1 |
| 17 | Jerome Baker | CLE | LB | 1 |
| 18 | Ronnie Harrison Jr. | MIA | LB | 1 |
| 19 | Rasul Douglas | MIA | CB | 1 |
| 20 | Isaiah Simmons | CAR | S | 1 |
| 21 | Tre Brown | NYJ | CB | 1 |
| 22 | Brian Branch | DET | S | 1 |
| 23 | Greg Newsome II | NYG | CB | 1 |
| 24 | Tyrann Mathieu | KC | UNK | 1 |
| 25 | Darius Slay | BUF | CB | 1 |