Troy Hill led the NFL in pick sixes in the 2020 regular season with 2.
Next came Montez Sweat (1) and J.J. Watt (1) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Pick Sixes |
|---|---|---|---|---|
| 1 | Troy Hill | CAR | UNK | 2 |
| 2 | Montez Sweat | CHI | DE | 1 |
| 3 | J.J. Watt | ARI | UNK | 1 |
| 4 | Deion Jones | TB | LB | 1 |
| 5 | Kyler Fackrell | LAC | UNK | 1 |
| 6 | Joe Schobert | PIT | UNK | 1 |
| 7 | Alex Singleton | DEN | LB | 1 |
| 8 | Robert Spillane | NE | LB | 1 |
| 9 | Khari Willis | IND | UNK | 1 |
| 10 | Kenny Moore II | IND | CB | 1 |
| 11 | Kam Curl | LAR | S | 1 |
| 12 | Javon Kinlaw | WSH | DT | 1 |
| 13 | Taron Johnson | LV | CB | 1 |
| 14 | Kenny Young | BAL | UNK | 1 |
| 15 | Sione Takitaki | MIN | LB | 1 |
| 16 | Ronnie Harrison Jr. | MIA | LB | 1 |
| 17 | Devin McCourty | NE | UNK | 1 |
| 18 | Joe Haden | PIT | UNK | 1 |
| 19 | Janoris Jenkins | SF | UNK | 1 |
| 20 | Josh Norman | SF | UNK | 1 |
| 21 | Xavier Rhodes | IND | UNK | 1 |
| 22 | Tyrann Mathieu | KC | UNK | 1 |
| 23 | T.J. Carrie | CLE | UNK | 1 |
| 24 | Pierre Desir | IND | UNK | 1 |
| 25 | Daniel Sorensen | KC | UNK | 1 |