Andrew Van Ginkel led the NFL in pick sixes in the 2024 regular season with 2.
Next came Marlon Humphrey (1) and Jaire Alexander (1) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Pick Sixes |
|---|---|---|---|---|
| 1 | Andrew Van Ginkel | MIN | LB | 2 |
| 2 | Marlon Humphrey | BAL | CB | 1 |
| 3 | Jaire Alexander | PHI | CB | 1 |
| 4 | C.J. Gardner-Johnson | BUF | S | 1 |
| 5 | Nate Wiggins | BAL | CB | 1 |
| 6 | Leonard Williams | SEA | DT | 1 |
| 7 | Fred Warner | SF | LB | 1 |
| 8 | DeMarvion Overshown | DAL | LB | 1 |
| 9 | Matthew Judon | BUF | DE | 1 |
| 10 | Jimmie Ward | HOU | S | 1 |
| 11 | Dante Fowler Jr. | DAL | LB | 1 |
| 12 | Taron Johnson | LV | CB | 1 |
| 13 | Jessie Bates III | ATL | S | 1 |
| 14 | Jack Jones | SF | CB | 1 |
| 15 | Coby Bryant | CHI | S | 1 |
| 16 | Ja'Marcus Ingram | HOU | CB | 1 |
| 17 | Geno Stone | BUF | S | 1 |
| 18 | Troy Andersen | ATL | LB | 1 |
| 19 | Nik Bonitto | DEN | LB | 1 |
| 20 | Kerby Joseph | DET | S | 1 |
| 21 | Cam Taylor-Britt | IND | CB | 1 |
| 22 | Pat Surtain II | DEN | CB | 1 |
| 23 | Tyrique Stevenson Sr. | CHI | CB | 1 |
| 24 | Jaylen McCollough | LAR | S | 1 |
| 25 | Ja'Quan McMillian | DEN | CB | 1 |