Foyesade Oluokun led the NFL in tackles in the 2022 regular season with 184.
Next came Nick Bolton (180) and Roquan Smith (169) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Tackles |
|---|---|---|---|---|
| 1 | Foyesade Oluokun | JAX | LB | 184 |
| 2 | Nick Bolton | KC | LB | 180 |
| 3 | Roquan Smith | BAL | LB | 169 |
| 4 | Zaire Franklin | GB | LB | 167 |
| 5 | Alex Singleton | DEN | LB | 163 |
| 6 | Jordyn Brooks | MIA | LB | 161 |
| 7 | T.J. Edwards | CHI | LB | 159 |
| 8 | Rashaan Evans | ATL | UNK | 159 |
| 9 | C.J. Mosley | NYJ | UNK | 158 |
| 10 | Bobby Okereke | NYG | LB | 151 |
| 11 | Jalen Pitre | HOU | S | 147 |
| 12 | Drue Tranquill | KC | LB | 146 |
| 13 | Bobby Wagner | WSH | LB | 140 |
| 14 | Eric Kendricks | SF | LB | 137 |
| 15 | Cody Barton | TEN | LB | 136 |
| 16 | Shaq Thompson | BUF | LB | 135 |
| 17 | Fred Warner | SF | LB | 130 |
| 18 | Jordan Hicks | MIN | UNK | 129 |
| 19 | Josey Jewell | CAR | UNK | 128 |
| 20 | Dre Greenlaw | SF | LB | 127 |
| 21 | Ja'Whaun Bentley | NE | UNK | 125 |
| 22 | Alex Anzalone | TB | LB | 125 |
| 23 | Jonathan Owens | IND | S | 125 |
| 24 | Devin White | LV | LB | 124 |
| 25 | Lavonte David | TB | LB | 124 |