Zach Cunningham led the NFL in tackles in the 2020 regular season with 164.
Next came Jaylon Smith (154) and Blake Martinez (151) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Tackles |
|---|---|---|---|---|
| 1 | Zach Cunningham | DET | LB | 164 |
| 2 | Jaylon Smith | NYG | UNK | 154 |
| 3 | Blake Martinez | GB | UNK | 151 |
| 4 | Joe Schobert | PIT | UNK | 141 |
| 5 | Devin White | LV | LB | 140 |
| 6 | Roquan Smith | BAL | LB | 139 |
| 7 | Bobby Wagner | WSH | LB | 138 |
| 8 | Neville Hewitt | NYG | LB | 134 |
| 9 | Shaquille Leonard | IND | UNK | 132 |
| 10 | Tyrell Adams | HOU | UNK | 125 |
| 11 | Fred Warner | SF | LB | 125 |
| 12 | Jordan Poyer | BUF | S | 124 |
| 13 | Alexander Johnson | SEA | UNK | 124 |
| 14 | Eric Wilson | MIN | LB | 122 |
| 15 | Alex Singleton | DEN | LB | 120 |
| 16 | Demario Davis | NYJ | LB | 119 |
| 17 | Tremaine Edmunds | NYG | LB | 119 |
| 18 | Jon Bostic | WSH | UNK | 118 |
| 19 | Budda Baker | ARI | S | 118 |
| 20 | Myles Jack | PIT | UNK | 118 |
| 21 | Jordan Hicks | MIN | UNK | 118 |
| 22 | Jeremy Chinn | LV | S | 117 |
| 23 | Foyesade Oluokun | JAX | LB | 117 |
| 24 | Lavonte David | TB | LB | 117 |
| 25 | Vonn Bell | CIN | UNK | 114 |