Foyesade Oluokun led the NFL in tackles in the 2021 regular season with 192.
Next came Jordyn Brooks (184) and Bobby Wagner (170) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Tackles |
|---|---|---|---|---|
| 1 | Foyesade Oluokun | JAX | LB | 192 |
| 2 | Jordyn Brooks | MIA | LB | 184 |
| 3 | Bobby Wagner | WSH | LB | 170 |
| 4 | C.J. Mosley | NYJ | UNK | 168 |
| 5 | Roquan Smith | BAL | LB | 163 |
| 6 | Denzel Perryman | LAC | LB | 154 |
| 7 | De'Vondre Campbell | SF | UNK | 146 |
| 8 | Kyzir White | SF | LB | 144 |
| 9 | Eric Kendricks | SF | LB | 143 |
| 10 | Cole Holcomb | PIT | LB | 142 |
| 11 | Deion Jones | TB | LB | 137 |
| 12 | Fred Warner | SF | LB | 137 |
| 13 | Alex Singleton | DEN | LB | 137 |
| 14 | Bobby Okereke | NYG | LB | 132 |
| 15 | T.J. Edwards | CHI | LB | 130 |
| 16 | Tae Crowder | NYG | UNK | 130 |
| 17 | Devin White | LV | LB | 128 |
| 18 | Minkah Fitzpatrick | NYJ | S | 124 |
| 19 | Shaquille Leonard | IND | UNK | 122 |
| 20 | Jalen Thompson | DAL | S | 121 |
| 21 | Derwin James Jr. | LAC | S | 118 |
| 22 | Logan Ryan | SF | UNK | 117 |
| 23 | Jordan Hicks | MIN | UNK | 116 |
| 24 | Johnathan Abram | SEA | UNK | 116 |
| 25 | Harrison Smith | MIN | S | 114 |