Shaquille Leonard led the NFL in tackles in the 2018 regular season with 163.
Next came Blake Martinez (144) and Leighton Vander Esch (140) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Tackles |
|---|---|---|---|---|
| 1 | Shaquille Leonard | IND | UNK | 163 |
| 2 | Blake Martinez | GB | UNK | 144 |
| 3 | Leighton Vander Esch | DAL | UNK | 140 |
| 4 | Bobby Wagner | WSH | LB | 138 |
| 5 | Anthony Hitchens | KC | UNK | 135 |
| 6 | Telvin Smith | JAX | UNK | 134 |
| 7 | Mason Foster | WSH | UNK | 133 |
| 8 | Luke Kuechly | CAR | UNK | 130 |
| 9 | Tahir Whitehead | LV | UNK | 126 |
| 10 | Cory Littleton | HOU | UNK | 125 |
| 11 | Kiko Alonso | NO | UNK | 125 |
| 12 | Fred Warner | SF | LB | 124 |
| 13 | Roquan Smith | BAL | LB | 122 |
| 14 | Jaylon Smith | NYG | UNK | 121 |
| 15 | Avery Williamson | NYJ | UNK | 121 |
| 16 | Tremaine Edmunds | NYG | LB | 121 |
| 17 | Antoine Bethea | NYG | UNK | 120 |
| 18 | Lavonte David | TB | LB | 119 |
| 19 | John Johnson III | LAR | UNK | 119 |
| 20 | Jamal Adams | LV | LB | 115 |
| 21 | Todd Davis | MIN | UNK | 114 |
| 22 | Wesley Woodyard | TEN | UNK | 113 |
| 23 | Jessie Bates III | ATL | S | 111 |
| 24 | Demario Davis | NYJ | LB | 110 |
| 25 | Shawn Williams | ATL | S | 110 |