Kevin Byard led the NFL in interceptions in the 2025 regular season with 7.
Next came Devin Lloyd (5) and Jaycee Horn (5) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Interceptions |
|---|---|---|---|---|
| 1 | Kevin Byard | NE | S | 7 |
| 2 | Devin Lloyd | CAR | LB | 5 |
| 3 | Jaycee Horn | CAR | CB | 5 |
| 4 | Ernest Jones IV | SEA | LB | 5 |
| 5 | Antonio Johnson | JAX | S | 5 |
| 6 | Xavier Watts | ATL | S | 5 |
| 7 | Nahshon Wright | NYJ | CB | 5 |
| 8 | Donte Jackson | LAC | CB | 4 |
| 9 | Jaylinn Hawkins | BAL | S | 4 |
| 10 | Marlon Humphrey | BAL | CB | 4 |
| 11 | Mike Jackson | CAR | CB | 4 |
| 12 | Cam Bynum | IND | S | 4 |
| 13 | Coby Bryant | CHI | S | 4 |
| 14 | Jalen Pitre | HOU | S | 4 |
| 15 | Derek Stingley Jr. | HOU | CB | 4 |
| 16 | Mike Sainristil | WSH | CB | 4 |
| 17 | Calen Bullock | HOU | S | 4 |
| 18 | Jordan Battle | CIN | S | 4 |
| 19 | Kamari Lassiter | HOU | CB | 4 |
| 20 | Tremaine Edmunds | NYG | LB | 4 |
| 21 | Tony Jefferson | LAC | S | 4 |
| 22 | Jalyx Hunt | PHI | LB | 3 |
| 23 | Derwin James Jr. | LAC | S | 3 |
| 24 | Marcus Jones | NE | CB | 3 |
| 25 | Jamel Dean | PIT | CB | 3 |