Xavien Howard led the NFL in interceptions in the 2020 regular season with 10.
Next came J.C. Jackson (9) and Tyrann Mathieu (6) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Interceptions |
|---|---|---|---|---|
| 1 | Xavien Howard | IND | CB | 10 |
| 2 | J.C. Jackson | LAC | UNK | 9 |
| 3 | Tyrann Mathieu | KC | UNK | 6 |
| 4 | Harrison Smith | MIN | S | 5 |
| 5 | Quandre Diggs | TEN | S | 5 |
| 6 | Justin Simmons | ATL | UNK | 5 |
| 7 | Amani Hooker | TEN | S | 4 |
| 8 | Kenny Moore II | IND | CB | 4 |
| 9 | Marcus Peters | BAL | UNK | 4 |
| 10 | Darnell Savage | PIT | S | 4 |
| 11 | Malcolm Butler | TEN | UNK | 4 |
| 12 | Kendall Fuller | MIA | UNK | 4 |
| 13 | Carlton Davis III | NE | CB | 4 |
| 14 | Minkah Fitzpatrick | NYJ | S | 4 |
| 15 | Darious Williams | LAR | CB | 4 |
| 16 | Jeff Heath | NO | S | 3 |
| 17 | Mike Hilton | IND | CB | 3 |
| 18 | Eric Wilson | MIN | LB | 3 |
| 19 | Malcolm Jenkins | NO | S | 3 |
| 20 | Joe Schobert | PIT | UNK | 3 |
| 21 | Tyus Bowser | BAL | UNK | 3 |
| 22 | L'Jarius Sneed | TEN | CB | 3 |
| 23 | Kam Curl | LAR | S | 3 |
| 24 | Tre'Davious White | BUF | CB | 3 |
| 25 | Trevon Diggs | DAL | CB | 3 |