Trevon Diggs led the NFL in interceptions in the 2021 regular season with 11.
Next came J.C. Jackson (8) and Amani Oruwariye (6) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Interceptions |
|---|---|---|---|---|
| 1 | Trevon Diggs | DAL | CB | 11 |
| 2 | J.C. Jackson | LAC | UNK | 8 |
| 3 | Amani Oruwariye | BAL | CB | 6 |
| 4 | Jordan Poyer | BUF | S | 5 |
| 5 | Justin Simmons | ATL | UNK | 5 |
| 6 | Micah Hyde | BUF | UNK | 5 |
| 7 | Kevin Byard | NE | S | 5 |
| 8 | Xavien Howard | IND | CB | 5 |
| 9 | Quandre Diggs | TEN | S | 5 |
| 10 | Rasul Douglas | MIA | CB | 5 |
| 11 | Xavier McKinney | GB | S | 5 |
| 12 | Taylor Rapp | BUF | S | 4 |
| 13 | Logan Wilson | CIN | LB | 4 |
| 14 | Kenny Moore II | IND | CB | 4 |
| 15 | Byron Murphy Jr. | MIN | CB | 4 |
| 16 | Adrian Phillips | NE | UNK | 4 |
| 17 | James Bradberry IV | PHI | UNK | 4 |
| 18 | Bobby McCain | WSH | UNK | 4 |
| 19 | Jalen Ramsey | PIT | CB | 4 |
| 20 | Shaquille Leonard | IND | UNK | 4 |
| 21 | Pat Surtain II | DEN | CB | 4 |
| 22 | Kyle Dugger | CIN | S | 4 |
| 23 | Anthony Barr | DAL | UNK | 3 |
| 24 | P.J. Williams | NO | UNK | 3 |
| 25 | Foyesade Oluokun | JAX | LB | 3 |